Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:A4_HUMAN
Description:amyloid beta (A4) precursor protein [Source:HGNC Symbol;Acc:620]
Location:chr21 q21.3
Node attribute:PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S730KKQYTsIHHGVAPP_amyloidPhosphoSitePlus
T668VDAAVtPEERHGSK3BHPRD
T729KKKQYtSIHHGRegPhos
S679EFRHDsGYEVHBeta-APPPhosphoSitePlus
S422QEKVEsLEQEAHPRD
T743VDAAVtPEERHAPP_amyloidPhosphoSitePlus
S366QEKVEsLEQEAHPRD
Y738MQQNGyENPTYHPRD
S441QEKVEsLEQEAAPP_E2; Exonuc_VII_L; ActPhosphoSitePlus
T743VDAAVtPEERHJNK3(MAPK10RegPhos
Y687YENPTyKFFEQHPRD
Y762YENPTyKFFEQHPRD; phosphoELM
Y115HFVIPyRCLVGAPP_NPhosphoSitePlus
Y757MQQNGyENPTYAPP_amyloidPhosphoSitePlus
T729KKKQYtSIHHGAPP_amyloidPhosphoSitePlus
T668VDAAVtPEERHHPRD
Y757MQQNGyENPTYHPRD; phosphoELM; RegPhos
T724VDAAVtPEERHCDK5HPRD
T668VDAAVtPEERHBACE2HPRD
T743VDAAVtPEERHGSK3B(GSK3 betaRegPhos
T761GYENPtYKFFEAPP_amyloidPhosphoSitePlus
T724VDAAVtPEERHGSK3BHPRD
T743VDAAVtPEERHGSK-3_betaphosphoELM
S441QEKVEsLEQEAHPRD
S206AEEDDsDVWWGCK1_groupRegPhos
T743VDAAVtPEERHQ9Y5Z0(Beta site APP cleaRegPhos
Y728LKKKQyTSIHHAPP_amyloidPhosphoSitePlus
S730KKQYTsIHHGVAPP-kinase I RegPhos
S198SDNVDsADAEECK2_groupRegPhos
T743VDAAVtPEERHCDK5HPRD; RegPhos
Y762YENPTyKFFEQAPP_amyloidPhosphoSitePlus
Y743YENPTyKFFEQHPRD
Y682MQQNGyENPTYHPRD
T743VDAAVtPEERHGSK3BHPRD; RegPhos

Dephosphorylation site
A4_HUMAN do not have dephosphorylation site.

Mutation site
A4_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000284981Pancreatic CancerNormal vs. CancertissueUp316215274
ENSP00000284981Brain CancerNormal vs. CancertissueDown0.4218056677
ENSP00000284981Brain CancerNormal vs. CancertissueDown0.4318056677

Hyperphosphorylation site
A4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANA4_HUMANkinase -> substrateRegPhos
CDK5_HUMANA4_HUMANkinase -> substrateHPRD; RegPhos
BACE2_HUMANA4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANA4_HUMANkinase -> substrateRegPhos
GSK3B_HUMANA4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
A4_HUMANG3P_HUMANotherKEGG
USF2_HUMANA4_HUMANTF -> target geneTRANSFAC
USF1_HUMANA4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04726Serotonergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0006378mRNA polyadenylationIEAbiological_process
GO:0030198extracellular matrix organizationISSbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0006378mRNA polyadenylationISSbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0016322neuron remodelingIEAbiological_process
GO:0008088axon cargo transportIEAbiological_process
GO:0007626locomotory behaviorISSbiological_process
GO:0008088axon cargo transportISSbiological_process
GO:0006417regulation of translationISSbiological_process
GO:0007176regulation of epidermal growth factor-activated reISSbiological_process
GO:0008542visual learningIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0043198dendritic shaftIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0051563smooth endoplasmic reticulum calcium ion homeostasIEAbiological_process
GO:0046914transition metal ion bindingIEAmolecular_function
GO:0043005neuron projectionIEAcellular_component
GO:0004867serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0070851growth factor receptor bindingIEAmolecular_function
GO:0045202synapseIDAcellular_component
GO:0043393regulation of protein bindingIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0048669collateral sprouting in absence of injuryISSbiological_process
GO:0006878cellular copper ion homeostasisISSbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0007617mating behaviorISSbiological_process
GO:0008542visual learningISSbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0016199axon midline choice point recognitionIEAbiological_process
GO:0001967suckling behaviorIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0051402neuron apoptotic processIMPbiological_process
GO:0016322neuron remodelingISSbiological_process
GO:0007409axonogenesisISSbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0005905coated pitIEAcellular_component
GO:0007626locomotory behaviorIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007176regulation of epidermal growth factor-activated reIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006897endocytosisISSbiological_process
GO:0010952positive regulation of peptidase activityIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0035235ionotropic glutamate receptor signaling pathwayIEAbiological_process
GO:0005794Golgi apparatusISScellular_component
GO:0031594neuromuscular junctionIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0000085G2 phase of mitotic cell cycleISSbiological_process
GO:0043197dendritic spineIDAcellular_component
GO:0051233spindle midzoneIEAcellular_component
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0030424axonISScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0000085G2 phase of mitotic cell cycleIEAbiological_process
GO:0031175neuron projection developmentISSbiological_process
GO:0008344adult locomotory behaviorISSbiological_process
GO:0045931positive regulation of mitotic cell cycleIEAbiological_process
GO:0016504peptidase activator activityIEAmolecular_function
GO:0003677DNA bindingISSmolecular_function
GO:0051402neuron apoptotic processIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0035253ciliary rootletIEAcellular_component
GO:0006897endocytosisIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0006417regulation of translationIEAbiological_process
GO:0051124synaptic growth at neuromuscular junctionIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0051425PTB domain bindingIPImolecular_function
GO:0006878cellular copper ion homeostasisIEAbiological_process
GO:0016199axon midline choice point recognitionISSbiological_process
GO:0030424axonIEAcellular_component
GO:0045931positive regulation of mitotic cell cycleISSbiological_process
GO:0016021integral to membraneISScellular_component
GO:0048669collateral sprouting in absence of injuryIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0035235ionotropic glutamate receptor signaling pathwayISSbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0016358dendrite developmentISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007617mating behaviorIEAbiological_process
GO:0050803regulation of synapse structure and activityIEAbiological_process
GO:0033130acetylcholine receptor bindingIPImolecular_function
GO:0050803regulation of synapse structure and activityISSbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process