| UniProt/SwissProt ID: | BACE2_HUMAN |
| Description: | beta-site APP-cleaving enzyme 2 [Source:HGNC Symbol;Acc:934] |
| Location: | chr21 q22.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y93 | SGRGYyLEMLI | Asp | PhosphoSitePlus |
| Y295 | LDCREyNADKA | HPRD | |
| Y295 | LDCREyNADKA | Asp | PhosphoSitePlus |
| S136 | DTERSsTYRSK | Asp | PhosphoSitePlus |
| T137 | TERSStYRSKG | Asp | PhosphoSitePlus |
| S368 | RDENSsRSFRI | Asp | PhosphoSitePlus |
| S140 | SSTYRsKGFDV | Asp | PhosphoSitePlus |
| Dephosphorylation site |
| BACE2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332979 | L362V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000332979 | L362V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000332979 | R139C | COSMIC | Skin Cancer | 21984974 | ENSP00000332979 | W154C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000333854 | T137A | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000332979 | W154C | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| BACE2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BACE2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BACE2_HUMAN | A4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05010 | Alzheimer's disease |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005768 | endosome | IEA | cellular_component |
| GO:0006509 | membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006508 | proteolysis | NAS | biological_process |
| GO:0016486 | peptide hormone processing | NAS | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0042985 | negative regulation of amyloid precursor protein b | IMP | biological_process |
| GO:0004190 | aspartic-type endopeptidase activity | IDA | molecular_function |