Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT1A_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [Source:HGNC Symbol;Acc:5286]
Location:chr5 q12.3
Node attribute:PPI(target); GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y215LMLVLyGRIFR7tm_1; TMPhosphoSitePlus
T196KDHGYtIYSTF7tm_1; TMPhosphoSitePlus
Y205TFGAFyIPLLL7tm_1; TMPhosphoSitePlus
S199GYTIYsTFGAF7tm_1; TMPhosphoSitePlus
T240KTGADtRHGAS7tm_1PhosphoSitePlus

Dephosphorylation site
5HT1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316244A60VCOSMICOvarian Cancer21720365
ENSP00000316244R181GCOSMICHead and Neck Cancer21798893
ENSP00000316244R227HCOSMICOvarian Cancer21720365
ENSP00000316244Y402*COSMICPancreatic Cancer

Differential expressed protein
5HT1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT1A_HUMANligand -> receptorHPMR
5HT1A_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT1A_HUMANGNAI1_HUMANGPCR -> GproteingpDB
5HT1A_HUMANGNAI3_HUMANGPCR -> GproteingpDB
5HT1A_HUMANGNAI2_HUMANGPCR -> GproteingpDB
IP3KA_HUMAN5HT1A_HUMANotherKEGG
MAZ_HUMAN5HT1A_HUMANTF -> target geneTRANSFAC
SP1_HUMAN5HT1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04726Serotonergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0007210serotonin receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0004993serotonin receptor activityIEAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007610behaviorTASbiological_process
GO:0005886plasma membraneTAScellular_component


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