| UniProt/SwissProt ID: | 5HT1A_HUMAN |
| Description: | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [Source:HGNC Symbol;Acc:5286] |
| Location: | chr5 q12.3 |
| Node attribute: | PPI(target); GPCR; receptor; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y215 | LMLVLyGRIFR | 7tm_1; TM | PhosphoSitePlus |
| T196 | KDHGYtIYSTF | 7tm_1; TM | PhosphoSitePlus |
| Y205 | TFGAFyIPLLL | 7tm_1; TM | PhosphoSitePlus |
| S199 | GYTIYsTFGAF | 7tm_1; TM | PhosphoSitePlus |
| T240 | KTGADtRHGAS | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| 5HT1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316244 | A60V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316244 | R181G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000316244 | R227H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316244 | Y402* | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| 5HT1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 5HT1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPH1_HUMAN | 5HT1A_HUMAN | ligand -> receptor | HPMR |
| 5HT1A_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1A_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1A_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT1A_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| IP3KA_HUMAN | 5HT1A_HUMAN | other | KEGG |
| MAZ_HUMAN | 5HT1A_HUMAN | TF -> target gene | TRANSFAC |
| SP1_HUMAN | 5HT1A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04726 | Serotonergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0007210 | serotonin receptor signaling pathway | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004993 | serotonin receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007610 | behavior | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |