| UniProt/SwissProt ID: | TPH1_HUMAN |
| Description: | tryptophan hydroxylase 1 [Source:HGNC Symbol;Acc:12008] |
| Location: | chr11 p15.1 |
| Node attribute: | ligand; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T225 | FLKERtGFSIR | Biopterin_H | PhosphoSitePlus |
| S58 | SKRRNsEFEIF | PKACa | RegPhos |
| S228 | ERTGFsIRPVA | Biopterin_H | PhosphoSitePlus |
| Y373 | TFQDVyFVSES | Biopterin_H | PhosphoSitePlus |
| S58 | SKRRNsEFEIF | PKA_group | phosphoELM; RegPhos |
| S58 | SKRRNsEFEIF | PKA_group | RegPhos |
| S58 | SKRRNsEFEIF | PRKACA | HPRD |
| Y404 | VKYNPyTRSIQ | Biopterin_H | PhosphoSitePlus |
| Y401 | PFGVKyNPYTR | Biopterin_H | PhosphoSitePlus |
| Dephosphorylation site |
| TPH1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000343550 | K415N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000250018 | K415N | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TPH1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TPH1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPH1_HUMAN | 5HT2A_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT4R_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT1B_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT1F_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT5A_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT6R_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT2C_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT1A_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | GPR26_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT7R_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT1E_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT2B_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | GP119_HUMAN | ligand -> receptor | HPMR |
| TPH1_HUMAN | 5HT1D_HUMAN | ligand -> receptor | HPMR |
| KPCA_HUMAN | TPH1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa04726 | Serotonergic synapse |
| hsa00380 | Tryptophan metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034641 | cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0046849 | bone remodeling | IEA | biological_process |
| GO:0007623 | circadian rhythm | IEA | biological_process |
| GO:0035902 | response to immobilization stress | IEA | biological_process |
| GO:0004510 | tryptophan 5-monooxygenase activity | IEA | molecular_function |
| GO:0060749 | mammary gland alveolus development | IEA | biological_process |
| GO:0030279 | negative regulation of ossification | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016597 | amino acid binding | IEA | molecular_function |
| GO:0009072 | aromatic amino acid family metabolic process | IEA | biological_process |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0046219 | indolalkylamine biosynthetic process | TAS | biological_process |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0042427 | serotonin biosynthetic process | IEA | biological_process |
| GO:0016714 | oxidoreductase activity, acting on paired donors, | IEA | molecular_function |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |