Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TSC2_HUMAN
Description:tuberous sclerosis 2 [Source:HGNC Symbol;Acc:12363]
Location:chr16 p13.3
Node attribute:PPI(target); PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1379LSFQPsQPLSKPhosphoSitePlus
S1420KARSQsGTLDGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T23LLGLGtPRPNPPhosphoSitePlus
S1764AYSNPsLPLVHPhosphoSitePlus
T1395RPRGYtISDSAHPRD
S1386PLSKSsSSPELPhosphoSitePlus; HPRD; phosphoELM
Y1736NPTDIyPSKWIRap_GAPPhosphoSitePlus
S981RCRSIsVSEHVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1326SPELQtLQDILHPRD
S939RARSTsLNERPAKT_groupRegPhos; SysPTM
S1252TALYKsLSVPAPhosphoSitePlus
S1365ERVVSsEGGRPPhosphoSitePlus
S1385QPLSKsSSSPEPhosphoSitePlus; HPRD; phosphoELM
T1462RPRGYtISDSAAKT_groupRegPhos
Y1571HGSYRyTEFLTHPRD; phosphoELM; RegPhos
S1130RDRVRsMSGGHPhosphoSitePlus; HPRD
Y1250RDTALyKSLSVPhosphoSitePlus
T1422RSQSGtLDGESPhosphoSitePlus
S1448GPLPSsSPRSPHPRD; phosphoELM
S1052GPESSsSPGVHHPRD
T1697EGLVDtSVAKIRap_GAPPhosphoSitePlus
S1418EVKARsQSGTLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1341SSSVSsQEEKSPhosphoSitePlus; HPRD; phosphoELM
S1388SKSSSsPELQTPhosphoSitePlus; HPRD; phosphoELM
S1271YSRSSsVSSQEHPRD
S960QGLNNsPPVKEPhosphoSitePlus
S540MARSLsPPPELPhosphoSitePlus; phosphoELM; RegPhos
S1798RKRLIsSVEDFRSK_groupphosphoELM; RegPhos; SysPTM
S1111LGSATsPGPRTHPRD
S1353KARSQsGTLDGHPRD
S1321SKSSSsPELQTHPRD
S1351EVKARsQSGTLHPRD
S1454SPRSPsGLRPRPhosphoSitePlus
S188LVKFNsCYLDEDUF3384PhosphoSitePlus
S540MARSLsPPPELErk2RegPhos
T938FRARStSLNERPhosphoSitePlus
S1385SSSPRsPSGLRHPRD
S1274SSSVSsQEEKSHPRD
S1297IERVVsSEGGRHPRD
Y602HYKHSyTLPIAHPRD
S1704VAKIVsDRNLPRap_GAPPhosphoSitePlus
T760EGFSRtDLHLATuberinPhosphoSitePlus
S1088RVRSMsGGHGLHPRD
S1320LSKSSsSPELQHPRD
S664TSGPLsPPTGPTuberinPhosphoSitePlus
S1267RTDAYsRSSSVHPRD
T927LSFDDtPEKDSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1798RKRLIsSVEDFRPS6KA1HPRD; SysPTM
S1050QSGPEsSSSPGHPRD
S1334RTDAYsRSSSVHPRD; phosphoELM
S1427TLDGEsAAWSAPhosphoSitePlus
S608TLPIAsSIRLQHPRD
Y1186TNLAAyVPLLTPhosphoSitePlus
S664TSGPLsPPTGPErk2(MAPK1RegPhos
S1382PLPSSsPRSPSHPRD
T1462RPRGYtISDSAPhosphoSitePlus
Y1760CEEAAySNPSLPhosphoSitePlus
S1731RKRLIsSVEDFHPRD
S1096GPESSsSPGVHPhosphoSitePlus; HPRD; phosphoELM
S1132RVRSMsGGHGLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1469SDSAPsRRGKRPhosphoSitePlus
T1462RPRGYtISDSAPKB_groupphosphoELM
Y1461LRPRGyTISDSPhosphoSitePlus; RegPhos
Y1571HGSYRyTEFLTRap_GAPPhosphoSitePlus
S1259SVPAAsTAKPPHPRD
S1798RKRLIsSVEDFPhosphoSitePlus; RegPhos; SysPTM
S939RARSTsLNERPPKB_groupphosphoELM; SysPTM
S1447EGPLPsSSPRSHPRD
S932TPEKDsFRARSPhosphoSitePlus
S1380EGPLPsSSPRSHPRD
S1381GPLPSsSPRSPHPRD
S1337AYSRSsSVSSQPhosphoSitePlus; HPRD; phosphoELM
S1387LSKSSsSPELQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S939RARSTsLNERPAKT1HPRD; RegPhos; SysPTM
Y1788EPTPGyEVGQRPhosphoSitePlus
S1094QSGPEsSSSPGHPRD
S664TSGPLsPPTGPErk2RegPhos
T1393SPELQtLQDILPhosphoSitePlus; HPRD; phosphoELM
S939RARSTsLNERPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1383PSQPLsKSSSSPhosphoSitePlus
S1254LYKSLsVPAASMAPKAPK2HPRD; phosphoELM; RegPhos
S1053PESSSsPGVHVHPRD
S664TSGPLsPPTGPMAPK1HPRD; phosphoELM
S1279SQEEKsLHAEEHPRD
S1086RDRVRsMSGGHHPRD
S1452SSSPRsPSGLRPhosphoSitePlus; HPRD; phosphoELM
S937SFRARsTSLNEPhosphoSitePlus
S1346SQEEKsLHAEEPhosphoSitePlus; HPRD
S1344DVGRLsPEVKAHPRD
S1215SVPAAsTAKPPHPRD
S1761EEAAYsNPSLPPhosphoSitePlus
S1155LGSATsPGPRTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1449PLPSSsPRSPSPhosphoSitePlus; HPRD; phosphoELM
S1338YSRSSsVSSQEPhosphoSitePlus; HPRD; phosphoELM
S1254LYKSLsVPAASPhosphoSitePlus
S1318QPLSKsSSSPEHPRD
S1364IERVVsSEGGRPhosphoSitePlus; HPRD; RegPhos
S1270AYSRSsSVSSQHPRD
S1319PLSKSsSSPELHPRD
S1371EGGRPsVDLSFPhosphoSitePlus
S1411DVGRLsPEVKAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S946NERPKsLRIARPhosphoSitePlus
T1462RPRGYtISDSAAKT1HPRD; RegPhos
S1799KRLISsVEDFTPhosphoSitePlus
S540MARSLsPPPELMAPK1HPRD
S1375PSVDLsFQPSQPhosphoSitePlus
S1097PESSSsPGVHVPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
TSC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399232S801NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000219476A210VBIOMARTBreast Cancer21930507, 21930502
ENSP00000219476V1711MCOSMICSkin Cancer21984974
ENSP00000219476R1795CCOSMICPancreatic Cancer21252315
ENSP00000219476A1141VCOSMICPancreatic Cancer21252315
ENSP00000219476S641RDing2008, COSMICLung Cancer18948947
ENSP00000219476V472MDing2008, COSMICLung Cancer18948947
ENSP00000219476Y1608DCOSMICOvarian Cancer21720365
ENSP00000219476D223NCOSMICCentral Nervous System Neoplasms18772396
ENSP00000219476N1651SCOSMICPancreatic Cancer21252315
ENSP00000219476V841ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000219476M1029ICOSMICOvarian Cancer21720365
ENSP00000219476V1500MCOSMICPancreatic Cancer21252315
ENSP00000399232A173VBIOMARTBreast Cancer21930507, 21930502
ENSP00000219476V1711MCOSMICSkin Cancer21984974
ENSP00000248099A210VBIOMARTBreast Cancer21930507, 21930502
ENSP00000219476A1141TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000219476S9*COSMICPancreatic Cancer21252315
ENSP00000219476D1629NCOSMICSkin Cancer21984974
ENSP00000219476V841ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000219476M1029ICOSMICOvarian Cancer21720365
ENSP00000219476Y1608DTCGAOvarian Cancer21720365, 18772890
ENSP00000219476R1289SDing2008, COSMICLung Cancer18948947
ENSP00000219476L45MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000219476A552TBIOMARTBrain Cancer21930507, 21930502
ENSP00000344383A210VBIOMARTBreast Cancer21930507, 21930502
ENSP00000219476D1629NCOSMICSkin Cancer21984974
ENSP00000219476Y1608DCOSMICOvarian Cancer21720365

Differential expressed protein
TSC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S664TuberinKKTSGPLsPPTGPPGtuberous sclerosis17671177PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A1_HUMANTSC2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANTSC2_HUMANkinase -> substrateRegPhos
MK01_HUMANTSC2_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
AKT1_HUMANTSC2_HUMANkinase -> substrateRegPhos
AKT3_HUMANTSC2_HUMANkinase -> substrateKEGG
MAPK2_HUMANTSC2_HUMANkinase -> substrateHPRD; RegPhos
AAPK1_HUMANTSC2_HUMANkinase -> substrateKEGG
KS6A6_HUMANTSC2_HUMANkinase -> substrateKEGG
TSC2_HUMANRHEB_HUMANotherKEGG
DDIT4_HUMANTSC2_HUMANotherKEGG
P53_HUMANTSC2_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014067negative regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0008285negative regulation of cell proliferationISSbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0006953acute-phase responseIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006469negative regulation of protein kinase activityISSbiological_process
GO:0006897endocytosisTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0033596TSC1-TSC2 complexIDAcellular_component
GO:0045184establishment of protein localizationIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0030426growth coneIEAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0019902phosphatase bindingIDAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005901caveolaIEAcellular_component
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIBAbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0030030cell projection organizationIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0008104protein localizationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0045121membrane raftIEAcellular_component
GO:0001843neural tube closureIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045792negative regulation of cell sizeIBAbiological_process
GO:0051726regulation of cell cycleIBAbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIEAbiological_process
GO:0005096GTPase activator activityIEAmolecular_function
GO:0001843neural tube closureISSbiological_process
GO:0030100regulation of endocytosisISSbiological_process
GO:0046626regulation of insulin receptor signaling pathwayIEAbiological_process
GO:0016192vesicle-mediated transportTASbiological_process
GO:0014067negative regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0046626regulation of insulin receptor signaling pathwayISSbiological_process
GO:0050918positive chemotaxisIEAbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006606protein import into nucleusISSbiological_process
GO:0051898negative regulation of protein kinase B signaling ISSbiological_process
GO:0050918positive chemotaxisISSbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0030100regulation of endocytosisIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0006606protein import into nucleusIEAbiological_process
GO:0043491protein kinase B signaling cascadeISSbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0044430cytoskeletal partIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032007negative regulation of TOR signaling cascadeIBAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0048009insulin-like growth factor receptor signaling pathISSbiological_process
GO:0005096GTPase activator activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0032007negative regulation of TOR signaling cascadeIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0008104protein localizationISSbiological_process
GO:0045792negative regulation of cell sizeIEAbiological_process
GO:0043547positive regulation of GTPase activityIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process