Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6A6_HUMAN
Description:ribosomal protein S6 kinase, 90kDa, polypeptide 6 [Source:HGNC Symbol;Acc:10435]
Location:chrX q21.1
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T94LVRKKtGPDAGPkinasePhosphoSitePlus
S555LYMDEsASADSPkinasePhosphoSitePlus
S521SEREAsDILYVPkinasePhosphoSitePlus
S232EKKAYsFCGTVHPRD; phosphoELM; SysPTM
T581NGLLLtPCYTAPkinasePhosphoSitePlus
S547RDLKPsNILYMPkinasePhosphoSitePlus
Y239CGTVEyMAPEVHPRD; phosphoELM
Y149TEGKLyLILDFPkinasePhosphoSitePlus
S372KTPKDsPGLPAHPRD; phosphoELM
S736LAQRRsMKKRTPhosphoSitePlus
S730PVAASsLAQRRPhosphoSitePlus
S83VLGQGsFGKVFPkinasePhosphoSitePlus
S389LFKGFsFVATSPkinase_CPhosphoSitePlus
Y525ASDILyVISKTPkinasePhosphoSitePlus
S389LFKGFsFVATSHPRD; phosphoELM
T236YSFCGtVEYMAHPRD; phosphoELM
S232EKKAYsFCGTVPkinasePhosphoSitePlus; SysPTM
Y231QEKKAySFCGTPkinasePhosphoSitePlus
T718ALTHKtFQPVLPhosphoSitePlus
S372KTPKDsPGLPAPkinase_CPhosphoSitePlus
T236YSFCGtVEYMAPkinasePhosphoSitePlus
Y239CGTVEyMAPEVPkinasePhosphoSitePlus
Y474EILMRyGQHPNPkinasePhosphoSitePlus
Y231QEKKAySFCGTHPRD; phosphoELM
Y437IGVGSySVCKRPkinasePhosphoSitePlus

Dephosphorylation site
KS6A6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262752Y140CHPINon-small cell lung carcinoma17344846
ENSP00000262752Y140CGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000262752R636CBIOMARTBreast Cancer21930507, 21930502
ENSP00000262752S258TGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000262752P464SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000262752E123*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
KS6A6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KS6A6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANKS6A6_HUMANkinase -> substrateKEGG
KS6A6_HUMANATF4_HUMANkinase -> substrateKEGG
KS6A6_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A6_HUMANTSC2_HUMANkinase -> substrateKEGG
IGF1_HUMANKS6A6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04010MAPK signaling pathway
hsa04114Oocyte meiosis
hsa04720Long-term potentiation
hsa04914Progesterone-mediated oocyte maturation
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0045992negative regulation of embryonic developmentISSbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006978DNA damage response, signal transduction by p53 clIMPbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:2000381negative regulation of mesoderm developmentISSbiological_process


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