Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT2B_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [Source:HGNC Symbol;Acc:5294]
Location:chr2 q37.1
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S404YRATKsVKTLRPhosphoSitePlus
T396FGRYItCNYRAPhosphoSitePlus

Dephosphorylation site
5HT2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000258400N52KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
5HT2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT2B_HUMANligand -> receptorHPMR
5HT2B_HUMANGNA11_HUMANGPCR -> GproteingpDB
5HT2B_HUMANGNAQ_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04726Serotonergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003007heart morphogenesisISSbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0003300cardiac muscle hypertrophyISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0070371ERK1 and ERK2 cascadeIMPbiological_process
GO:0005099Ras GTPase activator activityIEAmolecular_function
GO:0051378serotonin bindingIDAmolecular_function
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0071502cellular response to temperature stimulusISSbiological_process
GO:0051781positive regulation of cell divisionISSbiological_process
GO:0060548negative regulation of cell deathIMPbiological_process
GO:0014827intestine smooth muscle contractionIMPbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0071277cellular response to calcium ionIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0007210serotonin receptor signaling pathwayIMPbiological_process
GO:0042493response to drugIEAbiological_process
GO:0001755neural crest cell migrationISSbiological_process
GO:0050795regulation of behaviorIEAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0001819positive regulation of cytokine productionIDAbiological_process
GO:0042493response to drugIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005099Ras GTPase activator activityISSmolecular_function
GO:0051378serotonin bindingIEAmolecular_function
GO:0032320positive regulation of Ras GTPase activityIEAbiological_process
GO:0042310vasoconstrictionIMPbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:0019722calcium-mediated signalingIMPbiological_process
GO:0071502cellular response to temperature stimulusIEAbiological_process
GO:0001965G-protein alpha-subunit bindingIMPmolecular_function
GO:0048598embryonic morphogenesisISSbiological_process
GO:0016310phosphorylationIMPbiological_process
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0070588calcium ion transmembrane transportIMPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0050795regulation of behaviorIMPbiological_process
GO:0005262calcium channel activityIMPmolecular_function
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0014033neural crest cell differentiationISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0003007heart morphogenesisIEAbiological_process
GO:0070528protein kinase C signaling cascadeIMPbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0004993serotonin receptor activityIDAmolecular_function
GO:0003300cardiac muscle hypertrophyIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006182cGMP biosynthetic processIDAbiological_process
GO:0002031G-protein coupled receptor internalizationIMPbiological_process
GO:0051209release of sequestered calcium ion into cytosolIDAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIMPbiological_process
GO:0006661phosphatidylinositol biosynthetic processIMPbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0014033neural crest cell differentiationIEAbiological_process
GO:0051000positive regulation of nitric-oxide synthase activIDAbiological_process
GO:0007205protein kinase C-activating G-protein coupled receISSbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0010507negative regulation of autophagyIMPbiological_process
GO:0050715positive regulation of cytokine secretionISSbiological_process