Phosphorylation

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000363641	Gastric Cancer	Metastasis	cell line	Up	1.6	17022644
ENSP00000363641	Neoplasms by Histologic Type	Normal vs. Cancer	tissue	Up	1.9	18259946
ENSP00000363641	Hepatocellular Carcinoma	Normal vs. Cancer	tissue	Up		16335951
ENSP00000363641	Hepatocellular Carcinoma	Treatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)	tissue	Up		17593366
ENSP00000363641	Hepatocellular Carcinoma	Normal vs. Cancer	tissue	Up	1.8	19956837
ENSP00000363641	Gastric Cancer	Metastasis	cell line	Up	1.6	17022644
ENSP00000363641	Breast Cancer	Metastasis	cell line	Down	0.22	18582095
ENSP00000363641	Breast Cancer	Normal vs. Cancer	tissue	Up	3.3	20005186
ENSP00000363641	Breast Cancer	Normal vs. Cancer	cell line	Up	1.6	20543960
ENSP00000363641	Breast Cancer	Normal vs. Cancer	cell line	Up	1.5	20543960
ENSP00000363641	Breast Cancer	Normal vs. Cancer	cell line	Up	1.5	20543960
ENSP00000363641	acute myeloid leukemia	Treatment (none vs. NSC606985 treatment)	cell line	Up	9.7	17655343
ENSP00000363641	Gastric Cancer	Treatment (none vs. drug-resistant)	cell line	Down	0.74	20625496

Hyperphosphorylation site

THIO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
FAK1_HUMAN	THIO_HUMAN	kinase -> substrate	Robert H Newman (2013)
YES_HUMAN	THIO_HUMAN	kinase -> substrate	Robert H Newman (2013)
FAK2_HUMAN	THIO_HUMAN	kinase -> substrate	Robert H Newman (2013)
MARK2_HUMAN	THIO_HUMAN	kinase -> substrate	Robert H Newman (2013)

Function Annotation

KEGG Pathway

THIO_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007165	signal transduction	TAS	biological_process
GO:0033158	regulation of protein import into nucleus, translo	IDA	biological_process
GO:0055086	nucleobase-containing small molecule metabolic pro	TAS	biological_process
GO:0005739	mitochondrion	IEA	cellular_component
GO:0019899	enzyme binding	IEA	molecular_function
GO:0046826	negative regulation of protein export from nucleus	IEA	biological_process
GO:0030424	axon	IEA	cellular_component
GO:0005515	protein binding	IEA	molecular_function
GO:0044281	small molecule metabolic process	TAS	biological_process
GO:0007067	mitosis	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0035690	cellular response to drug	IEA	biological_process
GO:0009314	response to radiation	IDA	biological_process
GO:0015949	nucleobase-containing small molecule interconversi	TAS	biological_process
GO:0030425	dendrite	IEA	cellular_component
GO:0071455	cellular response to hyperoxia	IEA	biological_process
GO:0006351	transcription, DNA-dependent	IEA	biological_process
GO:0006928	cellular component movement	TAS	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0010269	response to selenium ion	IEA	biological_process
GO:0043388	positive regulation of DNA binding	IDA	biological_process
GO:0015037	peptide disulfide oxidoreductase activity	IEA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0043025	neuronal cell body	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005681	spliceosomal complex	IEA	cellular_component
GO:0035872	nucleotide-binding domain, leucine rich repeat con	TAS	biological_process
GO:0006662	glycerol ether metabolic process	IEA	biological_process
GO:0045087	innate immune response	TAS	biological_process
GO:0048678	response to axon injury	IEA	biological_process
GO:0015035	protein disulfide oxidoreductase activity	IEA	molecular_function
GO:0022900	electron transport chain	IEA	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0014823	response to activity	IEA	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0055114	oxidation-reduction process	IDA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0009055	electron carrier activity	IEA	molecular_function
GO:0045454	cell redox homeostasis	IEA	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0071333	cellular response to glucose stimulus	IEA	biological_process
GO:0005576	extracellular region	IEA	cellular_component
GO:0097068	response to thyroxine stimulus	IEA	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IEA	biological_process
GO:0016999	antibiotic metabolic process	IEA	biological_process
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0071548	response to dexamethasone stimulus	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network