Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYH6_HUMAN
Description:myosin, heavy chain 6, cardiac muscle, alpha [Source:HGNC Symbol;Acc:7576]
Location:chr14 q11.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1364LQRVLsKANSEMyosin_tail_1; FilamentPhosphoSitePlus
T666MTNLRtTHPHFMyosin_headPhosphoSitePlus
S173DRENQsILITGMyosin_headPhosphoSitePlus
T1129LEAERtARAKVMyosin_tail_1PhosphoSitePlus
Y1310RGKLSyTQQMEMyosin_tail_1; FilamentPhosphoSitePlus
Y423VQQVYySIGALMyosin_headPhosphoSitePlus
S1368LSKANsEVAQWMyosin_tail_1; FilamentPhosphoSitePlus
Y1490KLKNAyEESLEMyosin_tail_1; Filament; PhosphoSitePlus
S1139VEKLRsDLSREMyosin_tail_1PhosphoSitePlus
T1723LHSQNtSLINQMyosin_tail_1PhosphoSitePlus
T662LNKLMtNLRTTMyosin_headPhosphoSitePlus
Y267ADIETyLLEKSMyosin_headPhosphoSitePlus
Y1377QWRTKyETDAIMyosin_tail_1; FilamentPhosphoSitePlus
S1720VQLLHsQNTSLMyosin_tail_1PhosphoSitePlus
Y411KVGNEyVTKGQMyosin_headPhosphoSitePlus
S650SFQTVsALHREMyosin_headPhosphoSitePlus
T1853RIKELtYQTEEMyosin_tail_1PhosphoSitePlus
T1353QYEEEtEAKAEMyosin_tail_1; Filament; PhosphoSitePlus
T667TNLRTtHPHFVMyosin_headPhosphoSitePlus
Y1462EWKQKyEESQSMyosin_tail_1; Filament; PhosphoSitePlus
S1142LRSDLsRELEEMyosin_tail_1PhosphoSitePlus
S1917ADIAEsQVNKLMyosin_tail_1PhosphoSitePlus
Y1261DQANEyRVKLEMyosin_tail_1; FilamentPhosphoSitePlus
T447TRINAtLETKQMyosin_headPhosphoSitePlus
Y1349LLREQyEEETEMyosin_tail_1; Filament; PhosphoSitePlus
T1311GKLSYtQQMEDMyosin_tail_1; FilamentPhosphoSitePlus
T1184DLEEAtLQHEAMyosin_tail_1PhosphoSitePlus
T1379RTKYEtDAIQRMyosin_tail_1; FilamentPhosphoSitePlus
T1190LQHEAtAAALRMyosin_tail_1PhosphoSitePlus
T167YQYMLtDRENQMyosin_headPhosphoSitePlus
S1724HSQNTsLINQKMyosin_tail_1PhosphoSitePlus
S1309TRGKLsYTQQMMyosin_tail_1; FilamentPhosphoSitePlus
Y554FKAKLyDNHLGMyosin_headPhosphoSitePlus
T413GNEYVtKGQSVMyosin_headPhosphoSitePlus
T1385DAIQRtEELEEMyosin_tail_1; FilamentPhosphoSitePlus
S1598QRVVDsLQTSLMyosin_tail_1PhosphoSitePlus
S1467YEESQsELESSMyosin_tail_1; Filament; PhosphoSitePlus
Y422SVQQVyYSIGAMyosin_headPhosphoSitePlus
T1375VAQWRtKYETDMyosin_tail_1; FilamentPhosphoSitePlus
S1632MEIQLsHANRMMyosin_tail_1PhosphoSitePlus
S1493NAYEEsLEHLEMyosin_tail_1; Filament; PhosphoSitePlus
Y162ISDNAyQYMLTMyosin_headPhosphoSitePlus
T2____MtDAQMAPhosphoSitePlus
S1896ANTNLsKFRKVMyosin_tail_1PhosphoSitePlus
S1201KKHADsVAELGMyosin_tail_1PhosphoSitePlus
T1893EEQANtNLSKFMyosin_tail_1PhosphoSitePlus
S1465QKYEEsQSELEMyosin_tail_1; Filament; PhosphoSitePlus
T1481ARSLStELFKLMyosin_tail_1; Filament; PhosphoSitePlus
S1602DSLQTsLDAETMyosin_tail_1PhosphoSitePlus
S1039DDLEGsLEQEKMyosin_tail_1PhosphoSitePlus
Y758IDHNQyKFGHTMyosin_headPhosphoSitePlus
Y1854IKELTyQTEEDMyosin_tail_1PhosphoSitePlus
Y164DNAYQyMLTDRMyosin_headPhosphoSitePlus
S1480EARSLsTELFKMyosin_tail_1; Filament; PhosphoSitePlus
T1601VDSLQtSLDAEMyosin_tail_1PhosphoSitePlus
S1478QKEARsLSTELMyosin_tail_1; Filament; PhosphoSitePlus
Y717PNRILyGDFRQMyosin_headPhosphoSitePlus

Dephosphorylation site
MYH6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348634G426ECOSMICSkin Cancer21984974
ENSP00000348634D1735VCOSMICHead and Neck Cancer21798893
ENSP00000386041R789HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000348634R789HCOSMICPancreatic Cancer
ENSP00000348634R872CCOSMICHead and Neck Cancer21798893
ENSP00000348634V1613ICOSMICHead and Neck Cancer21798893
ENSP00000348634R1128HCOSMICHepatocellular Carcinoma21822264
ENSP00000348634S868FCOSMICMelanoma21499247
ENSP00000386041E1529DBIOMARTBreast Cancer21930507, 21930502
ENSP00000348634G718RCOSMICSkin Cancer21984974
ENSP00000348634E1529DBIOMARTBreast Cancer21930507, 21930502
ENSP00000348634A619DCOSMICPancreatic Cancer21252315

Differential expressed protein
MYH6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYH6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RARA_HUMANMYH6_HUMANTF -> target geneTRANSFAC
THB_HUMANMYH6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MYH6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0055009atrial cardiac muscle tissue morphogenesisIMPbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006941striated muscle contractionIEAbiological_process
GO:0048739cardiac muscle fiber developmentISSbiological_process
GO:0030049muscle filament slidingIMPbiological_process
GO:0006941striated muscle contractionISSbiological_process
GO:0008016regulation of heart contractionIEAbiological_process
GO:0060420regulation of heart growthIEAbiological_process
GO:0003774motor activityIEAmolecular_function
GO:0001725stress fiberIEAcellular_component
GO:0008217regulation of blood pressureISSbiological_process
GO:0008217regulation of blood pressureIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0006936muscle contractionIDAbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0030016myofibrilISScellular_component
GO:0048739cardiac muscle fiber developmentIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045214sarcomere organizationISSbiological_process
GO:0045214sarcomere organizationIEAbiological_process
GO:0007522visceral muscle developmentISSbiological_process
GO:0030239myofibril assemblyIEAbiological_process
GO:0000146microfilament motor activityISSmolecular_function
GO:0016459myosin complexTAScellular_component
GO:0002027regulation of heart rateIDAbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0000146microfilament motor activityIEAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0002027regulation of heart rateIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0005859muscle myosin complexTAScellular_component
GO:0032982myosin filamentIEAcellular_component
GO:0030898actin-dependent ATPase activityIMPmolecular_function
GO:0008307structural constituent of muscleIDAmolecular_function
GO:0006200ATP catabolic processIDAbiological_process
GO:0016459myosin complexIEAcellular_component
GO:0030017sarcomereTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0055010ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0008016regulation of heart contractionISSbiological_process
GO:0007512adult heart developmentIEAbiological_process
GO:0030048actin filament-based movementIEAbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0030016myofibrilIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0043462regulation of ATPase activityIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0002026regulation of the force of heart contractionISSbiological_process
GO:0030239myofibril assemblyISSbiological_process
GO:0043462regulation of ATPase activityISSbiological_process
GO:0030018Z discIEAcellular_component
GO:0007512adult heart developmentIMPbiological_process
GO:0007522visceral muscle developmentIEAbiological_process
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process