Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGFR1_HUMAN
Description:transforming growth factor, beta receptor 1 [Source:HGNC Symbol;Acc:11772]
Location:chr9 q22.33
Node attribute:PPI(source); PPI(target); substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S172DRPFIsEGTTLTGFBR2HPRD
S191TSGSGsGLPLLTGF_beta_GSPhosphoSitePlus
T185LIYDMtTSGSGTGF_beta_GSPhosphoSitePlus
T176ISEGTtLKDLITGFBR2HPRD
S187YDMTTsGSGSGRegPhos
T176ISEGTtLKDLITGF_beta_GSPhosphoSitePlus
S210IVLQEsIGKGRPkinasePhosphoSitePlus
T185LIYDMtTSGSGRegPhos
T186IYDMTtSGSGSTGF_beta_GSPhosphoSitePlus
S172DRPFIsEGTTLTGFbR2RegPhos
T200LLVQRtIARTITGF_beta_GSPhosphoSitePlus
T298NRYTVtVEGMIPkinasePhosphoSitePlus
T186IYDMTtSGSGSRegPhos
Y295DYLNRyTVTVEHPRD
T204RTIARtIVLQEPhosphoSitePlus
S191TSGSGsGLPLLRegPhos
S172DRPFIsEGTTLPhosphoSitePlus
T176ISEGTtLKDLITGFbR2RegPhos
S189MTTSGsGSGLPRegPhos
T298NRYTVtVEGMIHPRD
S189MTTSGsGSGLPTGF_beta_GSPhosphoSitePlus
S165NEEDPsLDRPFPhosphoSitePlus
S187YDMTTsGSGSGTGF_beta_GSPhosphoSitePlus

Dephosphorylation site
TGFR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364133I147VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364133Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
TGFR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDF9_HUMANTGFR1_HUMANligand -> receptorHPMR
TGFR1_HUMANSMAD1_HUMANkinase -> substrateHPRD
TGFR1_HUMANSMAD2_HUMANkinase -> substrateKEGG; HPRD
ZAGL2_HUMANTGFR1_HUMANkinase -> substrateRegPhos
TGFR2_HUMANTGFR1_HUMANkinase -> substrateHPRD
TGFB1_HUMANTGFR1_HUMANotherKEGG
TGFR1_HUMANDAXX_HUMANotherKEGG
SP1_HUMANTGFR1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa05166HTLV-I infection
hsa04520Adherens junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05210Colorectal cancer
hsa04380Osteoclast differentiation
hsa04350TGF-beta signaling pathway
hsa05220Chronic myeloid leukemia
hsa05212Pancreatic cancer
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019838growth factor bindingIPImolecular_function
GO:0043393regulation of protein bindingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048762mesenchymal cell differentiationTASbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0008354germ cell migrationIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0048844artery morphogenesisIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0010468regulation of gene expressionIEAbiological_process
GO:0044459plasma membrane partIDAcellular_component
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0070723response to cholesterolIEAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisISSbiological_process
GO:0043542endothelial cell migrationIEAbiological_process
GO:0030199collagen fibril organizationISSbiological_process
GO:0032331negative regulation of chondrocyte differentiationIEAbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0070022transforming growth factor beta receptor homodimerICcellular_component
GO:0001501skeletal system developmentIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0009791post-embryonic developmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0004514nicotinate-nucleotide diphosphorylase (carboxylatiIEAmolecular_function
GO:0001701in utero embryonic developmentISSbiological_process
GO:0048870cell motilityIMPbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0051272positive regulation of cellular component movementIMPbiological_process
GO:0030199collagen fibril organizationIEAbiological_process
GO:0005923tight junctionIDAcellular_component
GO:0060391positive regulation of SMAD protein import into nuIDAbiological_process
GO:0070411I-SMAD bindingIPImolecular_function
GO:0042060wound healingTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005114type II transforming growth factor beta receptor bIDAmolecular_function
GO:0001837epithelial to mesenchymal transitionIDAbiological_process
GO:0008354germ cell migrationISSbiological_process
GO:0001822kidney developmentISSbiological_process
GO:0001937negative regulation of endothelial cell proliferatIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005025transforming growth factor beta receptor activity,IDAmolecular_function
GO:0004675transmembrane receptor protein serine/threonine kiIDAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0050431transforming growth factor beta bindingIMPmolecular_function
GO:0007179transforming growth factor beta receptor signalingIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0050431transforming growth factor beta bindingIEAmolecular_function
GO:0060037pharyngeal system developmentIEAbiological_process
GO:0071560cellular response to transforming growth factor beIDAbiological_process
GO:0060021palate developmentISSbiological_process
GO:0051491positive regulation of filopodium assemblyIEAbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060037pharyngeal system developmentISSbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0009435NAD biosynthetic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0009952anterior/posterior pattern specificationISSbiological_process
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0048663neuron fate commitmentISSbiological_process
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0031396regulation of protein ubiquitinationIDAbiological_process
GO:0032331negative regulation of chondrocyte differentiationISSbiological_process
GO:0048705skeletal system morphogenesisISSbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0001824blastocyst developmentIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0001501skeletal system developmentISSbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0048538thymus developmentISSbiological_process
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0070723response to cholesterolIDAbiological_process
GO:0060017parathyroid gland developmentIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0048663neuron fate commitmentIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0060017parathyroid gland developmentISSbiological_process
GO:0043062extracellular structure organizationTASbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0048844artery morphogenesisISSbiological_process
GO:0007165signal transductionIDAbiological_process