Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRAF3_HUMAN
Description:TNF receptor-associated factor 3 [Source:HGNC Symbol;Acc:12033]
Location:chr14 q32.32
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T29DRSAGtPVFVPPhosphoSitePlus
S9SKKMDsPGALQPhosphoSitePlus

Dephosphorylation site
TRAF3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376500T29MCOSMICLung Cancer20668451
ENSP00000376500S269LCOSMICBreast Cancer20668451
ENSP00000454207K436NCOSMICOvarian Cancer20668451
ENSP00000454207T29MCOSMICLung Cancer20668451
ENSP00000454207S269LCOSMICBreast Cancer20668451
ENSP00000376500K436NCOSMICOvarian Cancer20668451

Differential expressed protein
TRAF3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRAF3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TCAM1_HUMANTRAF3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05169Epstein-Barr virus infection
hsa04064NF-kappa B signaling pathway
hsa05168Herpes simplex infection
hsa05160Hepatitis C

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0001817regulation of cytokine productionIEAbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0002224toll-like receptor signaling pathwayIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0032088negative regulation of NF-kappaB transcription facIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0035631CD40 receptor complexIEAcellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031996thioesterase bindingIPImolecular_function
GO:0004842ubiquitin-protein ligase activityTASmolecular_function
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0005768endosomeIEAcellular_component
GO:0006917induction of apoptosisTASbiological_process
GO:0030162regulation of proteolysisIEAbiological_process
GO:0050688regulation of defense response to virusIEAbiological_process
GO:0032648regulation of interferon-beta productionIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0001817regulation of cytokine productionISSbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0033209tumor necrosis factor-mediated signaling pathwayIMPbiological_process


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