Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLR3_HUMAN
Description:toll-like receptor 3 [Source:HGNC Symbol;Acc:11849]
Location:chr4 q35.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S205KKLELsSNQIKPhosphoSitePlus; HPRD
Y383LINLKyLSLSNLRR_8PhosphoSitePlus
T391LSNSFtSLRTLLRR_8PhosphoSitePlus
Y858EEIPDyKLNHATIRPhosphoSitePlus
Y759FEYAAyIIHAYTIRPhosphoSitePlus
S392SNSFTsLRTLTLRR_8PhosphoSitePlus
Y759FEYAAyIIHAYphosphoELM
S206KLELSsNQIKEPhosphoSitePlus; HPRD
T818IIFVItHHLLKHPRD
S350KIDDFsFQWLKLRR_8PhosphoSitePlus
T72PAANFtRYSQLLRR_8PhosphoSitePlus
T818IIFVItHHLLKTIRPhosphoSitePlus

Dephosphorylation site
TLR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296795L149VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000296795T262ACOSMICOvarian Cancer21720365
ENSP00000296795L469VCOSMICOvarian Cancer21720365
ENSP00000296795Q838HCOSMICHead and Neck Cancer21798893
ENSP00000296795T262ATCGAOvarian Cancer21720365, 18772890
ENSP00000296795S236TCOSMICLung Cancer20668451
ENSP00000296795L469VTCGAOvarian Cancer21720365, 18772890
ENSP00000296795D116HBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
TLR3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TLR3_HUMANTCAM1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04620Toll-like receptor signaling pathway
hsa05164Influenza A
hsa05160Hepatitis C
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0045080positive regulation of chemokine biosynthetic procIEAbiological_process
GO:0016020membraneNAScellular_component
GO:0000139Golgi membraneTAScellular_component
GO:0007250activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0004872receptor activityTASmolecular_function
GO:0009597detection of virusNASbiological_process
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0042346positive regulation of NF-kappaB import into nucleIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0045356positive regulation of interferon-alpha biosynthetIDAbiological_process
GO:0032728positive regulation of interferon-beta productionIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0009615response to virusIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006952defense responseIEAbiological_process
GO:0045359positive regulation of interferon-beta biosynthetiIMPbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034346positive regulation of type III interferon productIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0045078positive regulation of interferon-gamma biosynthetIDAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0004888transmembrane signaling receptor activityNASmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0045671negative regulation of osteoclast differentiationNASbiological_process
GO:0032481positive regulation of type I interferon productioIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0051607defense response to virusTASbiological_process
GO:0042742defense response to bacteriumTASbiological_process
GO:0003725double-stranded RNA bindingNASmolecular_function
GO:0034123positive regulation of toll-like receptor signalinIDAbiological_process
GO:0036020endolysosome membraneTAScellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0032722positive regulation of chemokine productionIDAbiological_process
GO:0006972hyperosmotic responseNASbiological_process