| UniProt/SwissProt ID: | TAB1_HUMAN |
| Description: | TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Source:HGNC Symbol;Acc:18157] |
| Location: | chr22 q13.1 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S438 | TLTNQsPTLTL | p38a(MAPK14 | RegPhos |
| S453 | THTQSsSSSSD | PhosphoSitePlus | |
| T185 | VANVGtNRALL | PP2C | PhosphoSitePlus |
| S456 | QSSSSsSDGGL | PhosphoSitePlus | |
| S423 | VNGAHsASTLD | MAPK14 | phosphoELM |
| S438 | TLTNQsPTLTL | PhosphoSitePlus | |
| S378 | SQPTPsPAPAA | PhosphoSitePlus | |
| S7 | LQSE | HPRD; phosphoELM; SysPTM | |
| Y179 | LNNKLyVANVG | PP2C | PhosphoSitePlus |
| T431 | TLDEAtPTLTN | p38a(MAPK14 | RegPhos |
| T431 | TLDEAtPTLTN | MAPK14 | phosphoELM |
| Y481 | GRVEPyVDFAE | PhosphoSitePlus | |
| S11 | RSLLQsEQQPS | PhosphoSitePlus | |
| S423 | VNGAHsASTLD | p38a(MAPK14 | RegPhos |
| S16 | SEQQPsWTDDL | PhosphoSitePlus | |
| S457 | SSSSSsDGGLF | PhosphoSitePlus | |
| T431 | TLDEAtPTLTN | PhosphoSitePlus | |
| S7 | AAQRRsLLQSE | PhosphoSitePlus; SysPTM | |
| S452 | NTHTQsSSSSS | PhosphoSitePlus | |
| Y488 | DFAEFyRLWSV | PhosphoSitePlus | |
| S438 | TLTNQsPTLTL | MAPK14 | phosphoELM |
| S423 | VNGAHsASTLD | PhosphoSitePlus | |
| Dephosphorylation site |
| TAB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TAB1_HUMAN do not have mutation site. |
| Differential expressed protein |
| TAB1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TAB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK14_HUMAN | TAB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| IL1R1_HUMAN | TAB1_HUMAN | other | KEGG |
| TNR1A_HUMAN | TAB1_HUMAN | other | KEGG |
| TAB1_HUMAN | M3K7_HUMAN | other | KEGG |
| CD14_HUMAN | TAB1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa05145 | Toxoplasmosis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05140 | Leishmaniasis |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05168 | Herpes simplex infection |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008047 | enzyme activator activity | TAS | molecular_function |
| GO:0000187 | activation of MAPK activity | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0070423 | nucleotide-binding oligomerization domain containi | TAS | biological_process |
| GO:0007254 | JNK cascade | TAS | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0003007 | heart morphogenesis | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | TAS | biological_process |
| GO:0035872 | nucleotide-binding domain, leucine rich repeat con | TAS | biological_process |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | IEA | biological_process |
| GO:0010008 | endosome membrane | TAS | cellular_component |
| GO:0019209 | kinase activator activity | IEA | molecular_function |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | TAS | biological_process |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000185 | activation of MAPKKK activity | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0030324 | lung development | IEA | biological_process |