Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYSC_HUMAN
Description:seryl-tRNA synthetase [Source:HGNC Symbol;Acc:10537]
Location:chr1 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S368NIVSGsLNHAAtRNA-synt_2bPhosphoSitePlus
S241EVAQLsQFDEEHPRD; phosphoELM
Y248FDEELyKVIGKtRNA-synt_2bPhosphoSitePlus
S101ANLKVsQIKKVSeryl_tRNA_NPhosphoSitePlus
S255VIGKGsEKSDDtRNA-synt_2bPhosphoSitePlus
S241EVAQLsQFDEEtRNA-synt_2bPhosphoSitePlus
S262KSDDNsYDEKYtRNA-synt_2bPhosphoSitePlus
T501AARDVtLENRLPhosphoSitePlus

Dephosphorylation site
SYSC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000234677W43*COSMICCentral Nervous System Neoplasms18772396
ENSP00000234677R20QCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000234677Gastric CancerMetastasiscell lineUp1.517022644
ENSP00000234677Gastric CancerMetastasiscell lineUp1.517022644

Hyperphosphorylation site
SYSC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK10_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SYSC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006418tRNA aminoacylation for protein translationTASbiological_process
GO:0003723RNA bindingTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0004828serine-tRNA ligase activityTASmolecular_function
GO:0004812aminoacyl-tRNA ligase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0097056selenocysteinyl-tRNA(Sec) biosynthetic processIEAbiological_process
GO:0006434seryl-tRNA aminoacylationIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006412translationTASbiological_process
GO:0008033tRNA processingTASbiological_process


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