| UniProt/SwissProt ID: | SYSC_HUMAN |
| Description: | seryl-tRNA synthetase [Source:HGNC Symbol;Acc:10537] |
| Location: | chr1 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S368 | NIVSGsLNHAA | tRNA-synt_2b | PhosphoSitePlus |
| S241 | EVAQLsQFDEE | HPRD; phosphoELM | |
| Y248 | FDEELyKVIGK | tRNA-synt_2b | PhosphoSitePlus |
| S101 | ANLKVsQIKKV | Seryl_tRNA_N | PhosphoSitePlus |
| S255 | VIGKGsEKSDD | tRNA-synt_2b | PhosphoSitePlus |
| S241 | EVAQLsQFDEE | tRNA-synt_2b | PhosphoSitePlus |
| S262 | KSDDNsYDEKY | tRNA-synt_2b | PhosphoSitePlus |
| T501 | AARDVtLENRL | PhosphoSitePlus | |
| Dephosphorylation site |
| SYSC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000234677 | W43* | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000234677 | R20Q | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000234677 | Gastric Cancer | Metastasis | cell line | Up | 1.5 | 17022644 | ENSP00000234677 | Gastric Cancer | Metastasis | cell line | Up | 1.5 | 17022644 |
| Hyperphosphorylation site |
| SYSC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK10_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1A_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK07_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAF1_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | SYSC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SYSC_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006418 | tRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004828 | serine-tRNA ligase activity | TAS | molecular_function |
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0097056 | selenocysteinyl-tRNA(Sec) biosynthetic process | IEA | biological_process |
| GO:0006434 | seryl-tRNA aminoacylation | IEA | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006412 | translation | TAS | biological_process |
| GO:0008033 | tRNA processing | TAS | biological_process |