Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHIP1_HUMAN
Description:inositol polyphosphate-5-phosphatase, 145kDa [Source:HGNC Symbol;Acc:6079]
Location:chr2 q37.1
Node attribute:Enzyme(target); Enzyme(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y373ILRKEyVFADSPhosphoSitePlus
S960PCRGEsPPTPPPhosphoSitePlus
Y40SISRAyALCVLSH2PhosphoSitePlus
T835QLPIYtPLTHHPhosphoSitePlus
S978KKFLPsTANRGPhosphoSitePlus
T423PPKKItSWFLSExo_endo_phosPhosphoSitePlus
S754YLEFHsSCLESPhosphoSitePlus
S243FDQQLsPGLRPPhosphoSitePlus
Y611IKQQQyADLLSExo_endo_phosPhosphoSitePlus
Y556RRNQNyMNILRExo_endo_phosPhosphoSitePlus
S289HEGPEsPHRPSPhosphoSitePlus
T880SSGPKtLKSLTPhosphoSitePlus
T1133EINQQtPPTPTPhosphoSitePlus
S934VKQTLsPDQQPPhosphoSitePlus
S744TLKTKsQTKFYPhosphoSitePlus
S205KTGSSsLPHLKPhosphoSitePlus
T963GESPPtPPGQPPhosphoSitePlus
T1003KNAGDtLPQEDPhosphoSitePlus
S274TSLLSsIEDKVPhosphoSitePlus
S1027YGSLSsFPKPAPhosphoSitePlus
Y796ISDPEyLLDQHPhosphoSitePlus
Y944PTAWSyDQPPKPhosphoSitePlus
Y221LCKELyGEVIRPhosphoSitePlus
Y1022FENPLyGSLSSPhosphoSitePlus; phosphoELM
Y865TREKLyDFVKTPhosphoSitePlus; phosphoELM
S755LEFHSsCLESFPhosphoSitePlus
Y834TQLPIyTPLTHPhosphoSitePlus
S971GQPPIsPKKFLPhosphoSitePlus
S1024NPLYGsLSSFPPhosphoSitePlus
T213HLKKLtTLLCKPhosphoSitePlus
Y915IINPNyMGVGPPhosphoSitePlus; phosphoELM
Y46ALCVLyRNCVYSH2PhosphoSitePlus
T1108QGKPKtPVSSQPhosphoSitePlus
T979KFLPStANRGLPhosphoSitePlus
T1136QQTPPtPTPRPPhosphoSitePlus
Y1161SKGRDyRDNTEPhosphoSitePlus
S951QPPKDsPLGPCPhosphoSitePlus
S1026LYGSLsSFPKPPhosphoSitePlus
Y339SEDKFySHKKIPhosphoSitePlus
S699SDIMTsDHSPVExo_endo_phosPhosphoSitePlus
Y644TFAPTyRFERLExo_endo_phosPhosphoSitePlus

Dephosphorylation site
SHIP1_HUMAN do not have dephosphorylation site.

Mutation site
SHIP1_HUMAN do not have mutation site.

Differential expressed protein
SHIP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y865GKTREKLyDFVKTERcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANSHIP1_HUMANkinase -> substrateNetPath
SHIP1_HUMANMTM1_HUMANenzyme catalysisKEGG
PTEN_HUMANSHIP1_HUMANenzyme catalysisKEGG
SHIP1_HUMANPTEN_HUMANenzyme catalysisKEGG
PI3R5_HUMANSHIP1_HUMANenzyme catalysisKEGG
INP4A_HUMANSHIP1_HUMANenzyme catalysisKEGG
SHIP1_HUMANLYN_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04070Phosphatidylinositol signaling system
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa00562Inositol phosphate metabolism
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030853negative regulation of granulocyte differentiationIEAbiological_process
GO:0050869negative regulation of B cell activationIEAbiological_process
GO:0034594phosphatidylinositol trisphosphate phosphatase actIEAmolecular_function
GO:0045579positive regulation of B cell differentiationIEAbiological_process
GO:0051425PTB domain bindingIEAmolecular_function
GO:0045656negative regulation of monocyte differentiationIEAbiological_process
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006796phosphate-containing compound metabolic processTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016064immunoglobulin mediated immune responseIEAbiological_process
GO:0030889negative regulation of B cell proliferationIEAbiological_process
GO:0045648positive regulation of erythrocyte differentiationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0045671negative regulation of osteoclast differentiationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0050777negative regulation of immune responseIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0009968negative regulation of signal transductionIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0004445inositol-polyphosphate 5-phosphatase activityIEAmolecular_function
GO:0045409negative regulation of interleukin-6 biosynthetic IEAbiological_process
GO:0045621positive regulation of lymphocyte differentiationIEAbiological_process
GO:0045659negative regulation of neutrophil differentiationIEAbiological_process
GO:0008340determination of adult lifespanIEAbiological_process
GO:0045779negative regulation of bone resorptionIEAbiological_process
GO:0007596blood coagulationTASbiological_process