Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SH2B1_HUMAN
Description:SH2B adaptor protein 1 [Source:HGNC Symbol;Acc:30417]
Location:chr16 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S157RFSLRsVGRSVPhosphoSitePlus
S154LKKRFsLRSVGPhosphoSitePlus
S165RSVRGsVRGILPhosphoSitePlus
Y624VVLVSyVPSSQPhosphoSitePlus
S102PGAEIsPHDLSPhosphoSitePlus
Y55ASHPQyAGPGAPhe_ZIPPhosphoSitePlus
S51RLYLAsHPQYAPhe_ZIPPhosphoSitePlus
S88ASGSLsPPILAPhosphoSitePlus; HPRD
S96ILAPLsPGAEIPhosphoSitePlus; HPRD
S161RSVGRsVRGSVPhosphoSitePlus

Dephosphorylation site
SH2B1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337163S627FCOSMICOvarian Cancer21720365
ENSP00000337163S51CCOSMICHead and Neck Cancer21798893
ENSP00000321221S627FTCGAOvarian Cancer21720365, 18772890
ENSP00000321221E349ATCGAOvarian Cancer21720365, 18772890
ENSP00000378903T484ABIOMARTGastric Cancer21930507, 21930502
ENSP00000337163E349ACOSMICOvarian Cancer21720365
ENSP00000337163P493LCOSMICSkin Cancer21984974

Differential expressed protein
SH2B1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SH2B1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANSH2B1_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSH2B1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
JAK1_HUMANSH2B1_HUMANkinase -> substrateRegPhos
MK01_HUMANSH2B1_HUMANkinase -> substrateRobert H Newman (2013)
PGFRB_HUMANSH2B1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005543phospholipid bindingIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0045840positive regulation of mitosisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:2000278regulation of DNA biosynthetic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0006928cellular component movementIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23