Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TENA_HUMAN
Description:tenascin C [Source:HGNC Symbol;Acc:5318]
Location:chr9 q33.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y2070TAQGQyELRVDFibrinogen_CPhosphoSitePlus
T1902EVQSEtALLTWfn3PhosphoSitePlus
S1020YRLNYsLPTGQfn3PhosphoSitePlus
Y1418YRVSIyGVIRGfn3PhosphoSitePlus
T1007TLLWKtPLAKFfn3PhosphoSitePlus
T1751PITGGtPSMVTfn3PhosphoSitePlus
T1701GRRSQtVSAIAPhosphoSitePlus
T1906ETALLtWRPPRHPRD
T1878PQKSStITAKFPhosphoSitePlus
T1492SGAERtAHISGfn3PhosphoSitePlus
T1906ETALLtWRPPRfn3PhosphoSitePlus
T2134TDSAItNCALSFibrinogen_CPhosphoSitePlus
T1760VTVDGtKTQTRfn3PhosphoSitePlus
S1703RSQTVsAIATTPhosphoSitePlus
Y491VCDDGyTGEDCEGF_2PhosphoSitePlus
S1889TTDLDsPRDLTfn3PhosphoSitePlus
T1885TAKFTtDLDSPPhosphoSitePlus
Y1019RYRLNySLPTGfn3PhosphoSitePlus
S72DLESAsGEKDLPhosphoSitePlus; HPRD
T1902EVQSEtALLTWHPRD
T1842KVPEItRTVSGfn3PhosphoSitePlus
S1846ITRTVsGNTVEfn3PhosphoSitePlus
T1502GLPPStDFIVYfn3PhosphoSitePlus
T1023NYSLPtGQWVGfn3PhosphoSitePlus
T800LKRVTtTRLDAPhosphoSitePlus
S1699SKGRRsQTVSAfn3PhosphoSitePlus
T2129TFDKDtDSAITFibrinogen_CPhosphoSitePlus
T1844PEITRtVSGNTfn3PhosphoSitePlus

Dephosphorylation site
TENA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265131M1782TBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131S70LCOSMICHead and Neck Cancer21984974
ENSP00000345861R322WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265131N297SBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131G892DCOSMICCentral Nervous System Neoplasms18772890
ENSP00000344555M1236TBIOMARTBreast Cancer21930507, 21930502
ENSP00000344400R322WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000344555R322WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265131R499HCOSMICCentral Nervous System Neoplasms18772890
ENSP00000344555N297SBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131E1897KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000345861M1145TBIOMARTBreast Cancer21930507, 21930502
ENSP00000344555K942NBIOMARTBreast Cancer21930507, 21930502
ENSP00000345861N297SBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131K942NBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131D644ECOSMICSkin Cancer21984974
ENSP00000265131Y779FCOSMICOvarian Cancer21720365
ENSP00000344400N297SBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131E970KCOSMICMelanoma21499247
ENSP00000344400M1418TBIOMARTBreast Cancer21930507, 21930502
ENSP00000344400K942NBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131R322WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265131A738TCOSMICCentral Nervous System Neoplasms18772396
ENSP00000345861K942NBIOMARTBreast Cancer21930507, 21930502
ENSP00000265131S1157FCOSMICHead and Neck Cancer21798897

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000345861Oral CancerNormal vs. CancertissueUp6619297561
ENSP00000345861Ovarian CancerMetastasiscell lineDown0.2317892554

Hyperphosphorylation site
TENA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TENA_HUMANSDC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007528neuromuscular junction developmentIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005614interstitial matrixIEAcellular_component
GO:0005604basement membraneIEAcellular_component
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0045545syndecan bindingIPImolecular_function
GO:0031012extracellular matrixIDAcellular_component
GO:0060739mesenchymal-epithelial cell signaling involved in IEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0009611response to woundingIEPbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0014012peripheral nervous system axon regenerationIEAbiological_process


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