Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:COMP_HUMAN
Description:cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:2227]
Location:chr19 p13.11
Node attribute:PPI(source)

Phosphorylation site
COMP_HUMAN do not have phosphorylation site.

Dephosphorylation site
COMP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222271D435HBIOMARTBreast Cancer21930507, 21930502
ENSP00000222271A71TCOSMICOvarian Cancer21720365
ENSP00000222271E457KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000222271breast ductal carcinomaMetastasistissueDown19624269
ENSP00000222271Pancreatic CancerNormal vs. CancertissueDown0.2716230073

Hyperphosphorylation site
COMP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COMP_HUMANCD47_HUMANotherKEGG
COMP_HUMANCD36_HUMANotherKEGG
COMP_HUMANLTBP1_HUMANotherKEGG
COMP_HUMANSDC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa04350TGF-beta signaling pathway
hsa04145Phagosome
hsa05144Malaria

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003417growth plate cartilage developmentIEAbiological_process
GO:0043395heparan sulfate proteoglycan bindingIDAmolecular_function
GO:0060173limb developmentIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008201heparin bindingIDAmolecular_function
GO:0005518collagen bindingIDAmolecular_function
GO:0001501skeletal system developmentTASbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0005201extracellular matrix structural constituentTASmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0009887organ morphogenesisTASbiological_process
GO:0005615extracellular spaceIDAcellular_component


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