| UniProt/SwissProt ID: | COMP_HUMAN |
| Description: | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:2227] |
| Location: | chr19 p13.11 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| COMP_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| COMP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000222271 | D435H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000222271 | A71T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000222271 | E457K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000222271 | breast ductal carcinoma | Metastasis | tissue | Down | 19624269 | ENSP00000222271 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.27 | 16230073 |
| Hyperphosphorylation site |
| COMP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COMP_HUMAN | CD47_HUMAN | other | KEGG |
| COMP_HUMAN | CD36_HUMAN | other | KEGG |
| COMP_HUMAN | LTBP1_HUMAN | other | KEGG |
| COMP_HUMAN | SDC1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04512 | ECM-receptor interaction |
| hsa04510 | Focal adhesion |
| hsa04350 | TGF-beta signaling pathway |
| hsa04145 | Phagosome |
| hsa05144 | Malaria |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003417 | growth plate cartilage development | IEA | biological_process |
| GO:0043395 | heparan sulfate proteoglycan binding | IDA | molecular_function |
| GO:0060173 | limb development | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008201 | heparin binding | IDA | molecular_function |
| GO:0005518 | collagen binding | IDA | molecular_function |
| GO:0001501 | skeletal system development | TAS | biological_process |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005201 | extracellular matrix structural constituent | TAS | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0009887 | organ morphogenesis | TAS | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |