Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TSP1_HUMAN
Description:thrombospondin 1 [Source:HGNC Symbol;Acc:11785]
Location:chr15 q14
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y319RPPLCyHNGVQVWCPhosphoSitePlus
Y565VKCTSyPDGSWPhosphoSitePlus
Y1058TRAQGySGLSVTSP_CPhosphoSitePlus
S569SYPDGsWKCGAPhosphoSitePlus
Y1022ERDDDyAGFVFTSP_CPhosphoSitePlus
Y1139DSGPIyDKTYATSP_CPhosphoSitePlus
S1033GYQSSsRFYVVTSP_CPhosphoSitePlus
Y1036SSSRFyVVMWKTSP_CPhosphoSitePlus
Y817NCQYVyNVDQRPhosphoSitePlus
Y1029GFVFGyQSSSRTSP_CPhosphoSitePlus
Y1126IRVVMyEGKKITSP_CPhosphoSitePlus
S564GVKCTsYPDGSPhosphoSitePlus
T563AGVKCtSYPDGPhosphoSitePlus

Dephosphorylation site
TSP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260356S417LCOSMICOvarian Cancer20826764
ENSP00000260356L240FCOSMICCentral Nervous System Neoplasms18772890
ENSP00000260356T523ABIOMARTGastric Cancer21930507, 21930502
ENSP00000260356G151STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000260356L240FTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000260356D170FTCGAOvarian Cancer21720365, 18772890
ENSP00000260356V506LTCGAOvarian Cancer21720365, 18772890
ENSP00000260356G151SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000260356R314WCOSMICHead and Neck Cancer21798893
ENSP00000260356D376NCOSMICCentral Nervous System Neoplasms18772396
ENSP00000260356V506LCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000260356Non-small cell lung carcinomaNormal vs. CancertissueUp18465169
ENSP00000260356Lung CancerNormal vs. CancertissueDown0.4817705522
ENSP00000260356Pancreatic CancerNormal vs. CancertissueDown0.0616215274
ENSP00000260356Breast CancerMetastasistissueDown0.2519053527
ENSP00000260356Esophageal CancerNormal vs. CancertissueUp2.119142970
ENSP00000260356Oral CancerNormal vs. CancertissueUp8519297561
ENSP00000260356hepatitis B virusNormal vs. Cancercell lineUp3.519187611
ENSP00000260356Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000260356Ovarian CancerMetastasiscell lineDown0.3517892554
ENSP00000260356Pancreatic CancerNormal vs. CancertissueUp2.516230073

Hyperphosphorylation site
TSP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TSP1_HUMANCD36_HUMANligand -> receptorHPMR
TSP1_HUMANSDC1_HUMANligand -> receptorHPMR
TSP1_HUMANCD47_HUMANligand -> receptorHPMR
P53_HUMANTSP1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04145Phagosome
hsa05219Bladder cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa04115p53 signaling pathway
hsa05144Malaria

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005178integrin bindingIMPmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0001786phosphatidylserine bindingIDAmolecular_function
GO:0031091platelet alpha granuleIDAcellular_component
GO:0010748negative regulation of plasma membrane long-chain IDAbiological_process
GO:0010763positive regulation of fibroblast migrationIDAbiological_process
GO:0005577fibrinogen complexIDAcellular_component
GO:0043032positive regulation of macrophage activationIDAbiological_process
GO:0042493response to drugIEPbiological_process
GO:2000379positive regulation of reactive oxygen species metIDAbiological_process
GO:0001948glycoprotein bindingNASmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0008201heparin bindingIDAmolecular_function
GO:0010811positive regulation of cell-substrate adhesionIEAbiological_process
GO:0002581negative regulation of antigen processing and presIDAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0017134fibroblast growth factor bindingIDAmolecular_function
GO:0045727positive regulation of translationIDAbiological_process
GO:0070051fibrinogen bindingIDAmolecular_function
GO:0032914positive regulation of transforming growth factor ISSbiological_process
GO:0032695negative regulation of interleukin-12 productionIDAbiological_process
GO:0010751negative regulation of nitric oxide mediated signaIDAbiological_process
GO:0002605negative regulation of dendritic cell antigen procIDAbiological_process
GO:0010596negative regulation of endothelial cell migrationIDAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0001937negative regulation of endothelial cell proliferatIMPbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0002544chronic inflammatory responseIEPbiological_process
GO:0016525negative regulation of angiogenesisIEAbiological_process
GO:0043536positive regulation of blood vessel endothelial ceIDAbiological_process
GO:0010757negative regulation of plasminogen activationIDAbiological_process
GO:0006955immune responseIEPbiological_process
GO:0070052collagen V bindingIDAmolecular_function
GO:0000187activation of MAPK activityIMPbiological_process
GO:0003417growth plate cartilage developmentIEAbiological_process
GO:0030511positive regulation of transforming growth factor IDAbiological_process
GO:0001666response to hypoxiaNASbiological_process
GO:0030169low-density lipoprotein particle bindingIDAmolecular_function
GO:0034605cellular response to heatNASbiological_process
GO:0040037negative regulation of fibroblast growth factor reIDAbiological_process
GO:0009749response to glucose stimulusIDAbiological_process
GO:0016477cell migrationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:2000462positive regulation of eukaryotic cell surface binIDAbiological_process
GO:0007155cell adhesionNASbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0010759positive regulation of macrophage chemotaxisISSbiological_process
GO:0042535positive regulation of tumor necrosis factor biosyIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0003197endocardial cushion developmentIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0043652engulfment of apoptotic cellIDAbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0050921positive regulation of chemotaxisIDAbiological_process
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0001953negative regulation of cell-matrix adhesionIDAbiological_process
GO:0005509calcium ion bindingNASmolecular_function
GO:0001968fibronectin bindingIDAmolecular_function
GO:0042327positive regulation of phosphorylationIMPbiological_process
GO:0051592response to calcium ionIDAbiological_process
GO:0050840extracellular matrix bindingIEAmolecular_function
GO:0051895negative regulation of focal adhesion assemblyTASbiological_process
GO:0030194positive regulation of blood coagulationIDAbiological_process
GO:0043394proteoglycan bindingTASmolecular_function
GO:0018149peptide cross-linkingIDAbiological_process
GO:0043236laminin bindingIDAmolecular_function
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0030141secretory granuleIDAcellular_component
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0051918negative regulation of fibrinolysisIDAbiological_process
GO:0032570response to progesterone stimulusTASbiological_process
GO:0010595positive regulation of endothelial cell migrationIDAbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0002040sprouting angiogenesisIMPbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0032026response to magnesium ionIDAbiological_process
GO:0042802identical protein bindingNASmolecular_function
GO:0010754negative regulation of cGMP-mediated signalingIDAbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0050431transforming growth factor beta bindingISSmolecular_function
GO:0009897external side of plasma membraneIDAcellular_component