| UniProt/SwissProt ID: | SAFB2_HUMAN |
| Description: | scaffold attachment factor B2 [Source:HGNC Symbol;Acc:21605] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S832 | SDKRLsEGRGL | PhosphoSitePlus; HPRD; phosphoELM | |
| S226 | GETCKsEPVKE | PhosphoSitePlus; HPRD; phosphoELM | |
| S330 | ELAEAsSEELA | PhosphoSitePlus; HPRD; phosphoELM | |
| S17 | GPGTAsLGPGV | PhosphoSitePlus | |
| Y825 | DGWGGyGSDKR | PhosphoSitePlus | |
| S194 | NTLETsSLNFK | PhosphoSitePlus; HPRD | |
| S287 | SSKADsLLAVV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S195 | TLETSsLNFKV | PhosphoSitePlus; HPRD; phosphoELM | |
| S245 | FAQDTsSVGPD | PhosphoSitePlus; HPRD; phosphoELM | |
| S85 | ATSKKsAKRCV | PhosphoSitePlus | |
| Y776 | RDRGQyQDHAI | PhosphoSitePlus | |
| S591 | KTTSRsKERSS | PhosphoSitePlus | |
| S11 | PGSGDsGPGTA | PhosphoSitePlus | |
| T339 | LAEAPtEAPSP | PhosphoSitePlus | |
| S331 | LAEASsEELAE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y741 | RRDDAyWPEGK | PhosphoSitePlus | |
| S444 | VTNARsPGARC | RRM_1 | PhosphoSitePlus |
| T471 | SHLHRtELHGR | RRM_1 | PhosphoSitePlus |
| T244 | PFAQDtSSVGP | PhosphoSitePlus; HPRD; phosphoELM | |
| S613 | KRDILsFDKIK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S349 | PEARDsKEDGR | PhosphoSitePlus; HPRD; phosphoELM | |
| S31 | GTRRLsELRVI | SAP | PhosphoSitePlus |
| S109 | GLEDDsRDGQE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S233 | PVKEEsSELEQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T440 | GAKVVtNARSP | RRM_1 | PhosphoSitePlus |
| S479 | HGRMIsVEKAK | RRM_1 | PhosphoSitePlus |
| T4 | PGSG | HPRD | |
| S54 | TGGNKsVLMER | HPRD | |
| S444 | VTNARsPGARC | HPRD | |
| S246 | AQDTSsVGPDR | PhosphoSitePlus; HPRD; phosphoELM | |
| S8 | ETLPGsGDSGP | HPRD | |
| S506 | KKEKLsSVDRH | HPRD | |
| S234 | VKEESsELEQP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y754 | AMEDRyRADFP | PhosphoSitePlus | |
| T201 | LNFKVtPDIEE | PhosphoSitePlus; HPRD | |
| S513 | VDRHHsVEIKI | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T4 | __MAEtLPGSG | PhosphoSitePlus | |
| S207 | PDIEEsLLEPE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T588 | ISVKTtSRSKE | PhosphoSitePlus | |
| S343 | PTEAPsPEARD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S827 | WGGYGsDKRLS | PhosphoSitePlus | |
| S31 | GTRRLsELRVI | HPRD | |
| Dephosphorylation site |
| SAFB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000252542 | T561I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000252542 | S132N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000252542 | H915N | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| SAFB2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SAFB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK2_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ARAF_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K7_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A4_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK11_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SAFB2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |