Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:S10AB_HUMAN
Description:S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:10488]
Location:chr1 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y30AGKDGyNYTLSHPRD; phosphoELM
Y32KDGYNyTLSKTS_100PhosphoSitePlus
Y24AVFQKyAGKDGS_100PhosphoSitePlus
S78GQLDFsEFLNLHPRD; SysPTM
T10SSPTEtERCIES_100PhosphoSitePlus
S71KLDTNsDGQLDphosphoELM
S94MACHDsFLKAVPhosphoSitePlus; HPRD; phosphoELM
S6MAKISsPTETEPhosphoSitePlus; SysPTM
T69MKKLDtNSDGQHPRD; SysPTM
S5_MAKIsSPTETPhosphoSitePlus
S16ERCIEsLIAVFS_100PhosphoSitePlus
S6TETEHPRD; phosphoELM; SysPTM
T33DGYNYtLSKTES_100PhosphoSitePlus
S71KLDTNsDGQLDefhandPhosphoSitePlus
T69MKKLDtNSDGQefhandPhosphoSitePlus; SysPTM
T10SSPTEtERCIEHPRD; phosphoELM
Y30AGKDGyNYTLSS_100PhosphoSitePlus
Y32KDGYNyTLSKTHPRD; phosphoELM
S5PTETHPRD; phosphoELM

Dephosphorylation site
S10AB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000271638*106CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000271638Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000271638Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000271638Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000271638Oral Premalignant LesionsNormal vs. CancertissueDown0.4819072117
ENSP00000271638Oral Premalignant LesionsNormal vs. CancertissueDown0.4519072117
ENSP00000271638Oral Premalignant LesionsNormal vs. CancertissueDown0.8419072117
ENSP00000271638Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000271638Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineDown0.4818491314
ENSP00000271638Gastric CancerMetastasiscell lineUp1.417022644
ENSP00000271638Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp1.818253933
ENSP00000271638Breast CancerNormal vs. CancertissueUp3.420005186
ENSP00000271638Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000271638Breast CancerNormal vs. CancertissueUp20560667
ENSP00000271638Neoplasms by Histologic TypeCancer vs. Cancer (ER- vs ER+)tissueUp320602252
ENSP00000271638Breast CancerNormal vs. CancertissueUp0.4620739354
ENSP00000271638Oral CancerNormal vs. CancertissueUp5.619691830
ENSP00000271638Pancreatic CancerNormal vs. CancertissueUp35019357035
ENSP00000271638Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineUp2.220944110

Hyperphosphorylation site
S10AB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
S10AB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008156negative regulation of DNA replicationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0048306calcium-dependent protein bindingIDAmolecular_function
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0001726ruffleIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0044548S100 protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process


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