| UniProt/SwissProt ID: | S10AB_HUMAN |
| Description: | S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:10488] |
| Location: | chr1 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y30 | AGKDGyNYTLS | HPRD; phosphoELM | |
| Y32 | KDGYNyTLSKT | S_100 | PhosphoSitePlus |
| Y24 | AVFQKyAGKDG | S_100 | PhosphoSitePlus |
| S78 | GQLDFsEFLNL | HPRD; SysPTM | |
| T10 | SSPTEtERCIE | S_100 | PhosphoSitePlus |
| S71 | KLDTNsDGQLD | phosphoELM | |
| S94 | MACHDsFLKAV | PhosphoSitePlus; HPRD; phosphoELM | |
| S6 | MAKISsPTETE | PhosphoSitePlus; SysPTM | |
| T69 | MKKLDtNSDGQ | HPRD; SysPTM | |
| S5 | _MAKIsSPTET | PhosphoSitePlus | |
| S16 | ERCIEsLIAVF | S_100 | PhosphoSitePlus |
| S6 | TETE | HPRD; phosphoELM; SysPTM | |
| T33 | DGYNYtLSKTE | S_100 | PhosphoSitePlus |
| S71 | KLDTNsDGQLD | efhand | PhosphoSitePlus |
| T69 | MKKLDtNSDGQ | efhand | PhosphoSitePlus; SysPTM |
| T10 | SSPTEtERCIE | HPRD; phosphoELM | |
| Y30 | AGKDGyNYTLS | S_100 | PhosphoSitePlus |
| Y32 | KDGYNyTLSKT | HPRD; phosphoELM | |
| S5 | PTET | HPRD; phosphoELM | |
| Dephosphorylation site |
| S10AB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271638 | *106C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000271638 | Non-small cell lung carcinoma | Metastasis | cell line | Up | 17537172 | ENSP00000271638 | Gastric Cancer | Metastasis | cell line | Up | 1.4 | 17022644 | ENSP00000271638 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000271638 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Down | 0.48 | 19072117 | ENSP00000271638 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Down | 0.45 | 19072117 | ENSP00000271638 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Down | 0.84 | 19072117 | ENSP00000271638 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.2 | 19072117 | ENSP00000271638 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Down | 0.48 | 18491314 | ENSP00000271638 | Gastric Cancer | Metastasis | cell line | Up | 1.4 | 17022644 | ENSP00000271638 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Up | 1.8 | 18253933 | ENSP00000271638 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3.4 | 20005186 | ENSP00000271638 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000271638 | Breast Cancer | Normal vs. Cancer | tissue | Up | 20560667 | ENSP00000271638 | Neoplasms by Histologic Type | Cancer vs. Cancer (ER- vs ER+) | tissue | Up | 3 | 20602252 | ENSP00000271638 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.46 | 20739354 | ENSP00000271638 | Oral Cancer | Normal vs. Cancer | tissue | Up | 5.6 | 19691830 | ENSP00000271638 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 350 | 19357035 | ENSP00000271638 | Pancreatic Cancer | Treatment (Gemcitabine-sensitive vs. Gemcitabine-resistant) | cell line | Up | 2.2 | 20944110 |
| Hyperphosphorylation site |
| S10AB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANPRB_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| YES_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| S10AB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008156 | negative regulation of DNA replication | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0048306 | calcium-dependent protein binding | IDA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0001726 | ruffle | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |