Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRP4B_HUMAN
Description:PRP4 pre-mRNA processing factor 4 homolog B (yeast) [Source:HGNC Symbol;Acc:17346]
Location:chr6 p25.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T576QSSTRtRSPSPPhosphoSitePlus; HPRD; phosphoELM
Y140LILQGyESGSEPhosphoSitePlus; HPRD; phosphoELM
S387PSRTLsPGRRAPhosphoSitePlus; HPRD; phosphoELM
S437PINRWsPTRRRPhosphoSitePlus; HPRD; phosphoELM
S507DKFKGsLSEGMPhosphoSitePlus
S184TTKKRsKSRSKPhosphoSitePlus
Y855LVSRFyRAPEIPkinasePhosphoSitePlus
S131EGKVQsGMGLIHPRD
S239DQARKsKSPTLPhosphoSitePlus; HPRD; phosphoELM
S23ANSEKsINEENPhosphoSitePlus; HPRD; phosphoELM
S568VPSEPsSPQSSHPRD
T439NRWSPtRRRSRPhosphoSitePlus; HPRD
S572PSSPQsSTRTRHPRD
S368SRRSRsPLLNDPhosphoSitePlus; HPRD; phosphoELM
S144GYESGsEEEGEPhosphoSitePlus; HPRD; phosphoELM
S277KDRKKsPIINEPhosphoSitePlus; HPRD; phosphoELM
S285INESRsRDRGKPhosphoSitePlus
S839DFGSAsHVADNPkinasePhosphoSitePlus
S283PIINEsRSRDRPhosphoSitePlus; HPRD
T259KARSPtDDKVKPhosphoSitePlus; HPRD; phosphoELM
S837LCDFGsASHVAPkinasePhosphoSitePlus
Y848DNDITpYLVSRHPRD
S201SDKKKsKGGIEPhosphoSitePlus
S32ENGEVsEDQSQPhosphoSitePlus; HPRD; phosphoELM
S519VEQESsSDDNLPhosphoSitePlus; HPRD; phosphoELM
S460LRRSRsPRRRSPhosphoSitePlus; phosphoELM
T574SPQSStRTRSPPhosphoSitePlus; HPRD
T385KSPSRtLSPGRPhosphoSitePlus; HPRD
S292DRGKKsRSPVDPhosphoSitePlus; HPRD; phosphoELM
S431RSKDAsPINRWPhosphoSitePlus; HPRD; phosphoELM
S578STRTRsPSPDDPhosphoSitePlus; HPRD; phosphoELM
S445RRRSRsPIRRRPhosphoSitePlus; phosphoELM
S623QNNGSsQKKLLHPRD
S41SQNKHsRHKKKPhosphoSitePlus
S636DMFTEsDDMFAPhosphoSitePlus
S562EDSNMsVPSEPHPRD
Y849NDITPyLVSRFPkinasePhosphoSitePlus
S142LQGYEsGSEEEPhosphoSitePlus; HPRD; phosphoELM
S354SPKRRsLSPKPPhosphoSitePlus; HPRD; phosphoELM
S394GRRAKsRSLERPhosphoSitePlus; HPRD
S383QSKSPsRTLSPPhosphoSitePlus; HPRD
S20MEDANsEKSINPhosphoSitePlus; HPRD; phosphoELM
S559YLAEDsNMSVPHPRD
S381SKQSKsPSRTLPhosphoSitePlus; HPRD
T847ADNDItPYLVSHPRD; phosphoELM
S294GKKSRsPVDLRPhosphoSitePlus; HPRD; phosphoELM
S443PTRRRsRSPIRPhosphoSitePlus; phosphoELM
S164RSSTRsSSTKGPhosphoSitePlus
S411RRRLSsPRTRPPhosphoSitePlus; HPRD; phosphoELM
S410ERRRLsSPRTRPhosphoSitePlus; HPRD; phosphoELM
S366DKSRRsRSPLLPhosphoSitePlus; HPRD; phosphoELM
S852TPYLVsRFYRAPkinasePhosphoSitePlus
S580RTRSPsPDDILPhosphoSitePlus; HPRD; phosphoELM
S87EVIDAsDKEGMphosphoELM
Y643DMFAAyFDSARPhosphoSitePlus
S349RRPGRsPKRRSPhosphoSitePlus; HPRD
S356KRRSLsPKPRDPhosphoSitePlus; HPRD; phosphoELM
T162GNRSStRSSSTPhosphoSitePlus
Y849NDITPyLVSRFHPRD; phosphoELM
S396RAKSRsLERKRPhosphoSitePlus; HPRD
T847ADNDItPYLVSPkinasePhosphoSitePlus
S8AAETQsLREQPHPRD
S565NMSVPsEPSSPPhosphoSitePlus; HPRD; phosphoELM
S458SPLRRsRSPRRPhosphoSitePlus; phosphoELM
S257IGKARsPTDDKPhosphoSitePlus; HPRD; phosphoELM
S166STRSSsTKGKLPhosphoSitePlus
T243KSKSPtLRRRSPhosphoSitePlus; HPRD
S87EIIDAsDKEGMPhosphoSitePlus
S852TPYLVsRFYRAHPRD; phosphoELM
S518KVEQEsSSDDNPhosphoSitePlus; HPRD; phosphoELM
Y554VQKYKyLAEDSPhosphoSitePlus; HPRD
S196RTRHRsDKKKSPhosphoSitePlus
S569PSEPSsPQSSTPhosphoSitePlus; HPRD; phosphoELM
S509FKGSLsEGMKVPhosphoSitePlus
S573SSPQSsTRTRSHPRD
S36VSEDQsQNKHSPhosphoSitePlus; HPRD; phosphoELM
S330PIKSPsKDASSPhosphoSitePlus; HPRD
S622EQNNGsSQKKLHPRD
S794IKAVRsYSQQLPkinasePhosphoSitePlus
S427SRRERsKDASPPhosphoSitePlus; HPRD; phosphoELM
S165SSTRSsSTKGKPhosphoSitePlus
S93DKEGMsPAKRTPhosphoSitePlus; phosphoELM
S328KKPIKsPSKDAPhosphoSitePlus; HPRD; phosphoELM
S520EQESSsDDNLEPhosphoSitePlus; HPRD; phosphoELM
S241ARKSKsPTLRRPhosphoSitePlus; HPRD; phosphoELM
T6SLREHPRD
Y674TDAEGyYRVNIPhosphoSitePlus

Dephosphorylation site
PRP4B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000433547R183*TCGAOvarian Cancer21720365, 18772890
ENSP00000337194F658LSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 17344846, 21930507, 21930502, 16959974, 17344846, 16959974 17344846
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194R183*TCGAOvarian Cancer21720365, 18772890
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194L664HCOSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194P570HCOSMICBreast Cancer20668451
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893
ENSP00000337194E598*COSMICHead and Neck Cancer21798893
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194W668XBIOMARTBreast Cancer21930507, 21930502
ENSP00000337194T574MCOSMICHead and Neck Cancer21798893
ENSP00000337194R183*COSMICOvarian Cancer21720365
ENSP00000337194K301RCOSMICHead and Neck Cancer21798893

Differential expressed protein
PRP4B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRP4B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PRP4B_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANGPBL1_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANRRAGC_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANZN485_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
PRP4B_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRP4B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005694chromosomeIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function