Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPARG_HUMAN
Description:peroxisome proliferator-activated receptor gamma [Source:HGNC Symbol;Acc:9236]
Location:chr3 p25.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S112KVEPAsPPYYSMAPK_groupRegPhos
T269ILTGKtTDKSPHPRD
S112KVEPAsPPYYSJNK1RegPhos
Y95VADYKyDLKLQPPARgamma_NPhosphoSitePlus
S112KVEPAsPPYYSMAPK8HPRD; phosphoELM
S112KVEPAsPPYYSMAPK1HPRD; phosphoELM
S84KVEPAsPPYYSMAPK8HPRD
S84KVEPAsPPYYSMAPK1HPRD
S112KVEPAsPPYYSJNK1(MAPK8RegPhos
Y102LKLQEyQSAIKPPARgamma_NPhosphoSitePlus
S112KVEPAsPPYYSErk2RegPhos
T241ILTGKtTDKSPHPRD
S273KTTDKsPFVIYPhosphoSitePlus
S112KVEPAsPPYYSPhosphoSitePlus
S112KVEPAsPPYYSErk2(MAPK1RegPhos

Dephosphorylation site
PPARG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000287820T4SCOSMICRenal Cancer20054297
ENSP00000287820H150YCOSMICSkin Cancer21984974
ENSP00000287820Q314PHPIColorectal Cancer10394368
ENSP00000380205L69RBIOMARTBreast Cancer21930507, 21930502
ENSP00000380210L69RBIOMARTBreast Cancer21930507, 21930502
ENSP00000287820L97RBIOMARTBreast Cancer21930507, 21930502
ENSP00000287820R316HHPIColorectal Cancer10394368
ENSP00000312472L69RBIOMARTBreast Cancer21930507, 21930502
ENSP00000380207L69RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PPARG_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPARG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANPPARG_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK08_HUMANPPARG_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
RORA_HUMANPPARG_HUMANTF -> target geneTRANSFAC
SRBP2_HUMANPPARG_HUMANTF -> target geneTRANSFAC
CEBPA_HUMANPPARG_HUMANTF -> target geneTRANSFAC
SRBP1_HUMANPPARG_HUMANTF -> target geneTRANSFAC
NFAC4_HUMANPPARG_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05016Huntington's disease
hsa04380Osteoclast differentiation
hsa05216Thyroid cancer
hsa05200Pathways in cancer
hsa03320PPAR signaling pathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0031100organ regenerationIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0050872white fat cell differentiationIEAbiological_process
GO:0033189response to vitamin AIEAbiological_process
GO:0042953lipoprotein transportIDAbiological_process
GO:0045600positive regulation of fat cell differentiationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0002674negative regulation of acute inflammatory responseIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0030224monocyte differentiationIDAbiological_process
GO:0007165signal transductionIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0032526response to retinoic acidIDAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0033613activating transcription factor bindingIDAmolecular_function
GO:0031000response to caffeineIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0008144drug bindingIDAmolecular_function
GO:0008217regulation of blood pressureIMPbiological_process
GO:0033993response to lipidISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0001012RNA polymerase II regulatory region DNA bindingIEAmolecular_function
GO:0046321positive regulation of fatty acid oxidationIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045713low-density lipoprotein particle receptor biosynthIDAbiological_process
GO:0060694regulation of cholesterol transporter activityICbiological_process
GO:0060336negative regulation of interferon-gamma-mediated sIMPbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0001890placenta developmentIEAbiological_process
GO:0048469cell maturationIDAbiological_process
GO:0046965retinoid X receptor bindingIDAmolecular_function
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIDAbiological_process
GO:0045598regulation of fat cell differentiationIEAbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0004955prostaglandin receptor activityTASmolecular_function
GO:0015909long-chain fatty acid transportIEAbiological_process
GO:0051974negative regulation of telomerase activityIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0019395fatty acid oxidationIEAbiological_process
GO:0010745negative regulation of macrophage derived foam celICbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0050544arachidonic acid bindingISSmolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0010871negative regulation of receptor biosynthetic proceIDAbiological_process
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0010887negative regulation of cholesterol storageIDAbiological_process
GO:0010891negative regulation of sequestering of triglyceridIDAbiological_process
GO:0055088lipid homeostasisTASbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0055098response to low-density lipoprotein particle stimuIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0009409response to coldIEAbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0048714positive regulation of oligodendrocyte differentiaIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0007584response to nutrientTASbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0035357peroxisome proliferator activated receptor signaliIMPbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function