Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PBX2_HUMAN
Description:pre-B-cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:8633]
Location:chrHSCHR6_MHC_MANN p
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S136EKGGGsAAAAAPBCPhosphoSitePlus
S159NSIEHsDYRSKHPRD; phosphoELM
T325TAVSVtQGGHSPhosphoSitePlus
S159NSIEHsDYRSKPBCPhosphoSitePlus
S151SGGGVsPDNSIHPRD; phosphoELM; SysPTM
S395GGQMYsPREMRPhosphoSitePlus
S105LSIRSsQEEEPPBCPhosphoSitePlus
S151SGGGVsPDNSIPBCPhosphoSitePlus; SysPTM
Y316EEANIyAVKTAPhosphoSitePlus
S105LSIRSsQEEEPHPRD; phosphoELM
S330TQGGHsRTSSPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S104GLSIRsSQEEEHPRD

Dephosphorylation site
PBX2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364190A77VCOSMICOvarian Cancer21720365

Differential expressed protein
PBX2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PBX2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDKL5_HUMANPBX2_HUMANkinase -> substrateRobert H Newman (2013)
TRIB3_HUMANPBX2_HUMANkinase -> substrateRobert H Newman (2013)
PBX2_HUMANCO5A2_HUMANTF -> target geneTRANSFAC
PBX2_HUMANUROK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PBX2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0009954proximal/distal pattern formationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0008134transcription factor bindingIPImolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function


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