| UniProt/SwissProt ID: | PAR3_HUMAN |
| Description: | coagulation factor II (thrombin) receptor-like 2 [Source:HGNC Symbol;Acc:3539] |
| Location: | chr5 q13.3 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y224 | ATVFLyMLPFF | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| PAR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296641 | L141F | COSMIC | Melanoma | 20016485 | ENSP00000296641 | F6V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PAR3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PAR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| THRB_HUMAN | PAR3_HUMAN | ligand -> receptor | HPMR |
| PAR3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| PAR3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| PAR3_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| PAR3_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| PAR3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| PAR3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0015057 | thrombin receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0009611 | response to wounding | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004435 | phosphatidylinositol phospholipase C activity | TAS | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |