Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAR2_HUMAN
Description:coagulation factor II (thrombin) receptor-like 1 [Source:HGNC Symbol;Acc:3538]
Location:chr5 q13.3
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S387KSSSYsSSSTTPhosphoSitePlus
S385SRKSSsYSSSSPhosphoSitePlus
S373KQMQVsLTSKKHPRD
S388SSSYSsSSTTVPhosphoSitePlus
S384HSRKSsSYSSSPhosphoSitePlus
T391YSSSStTVKTSPhosphoSitePlus
S380TSKKHsRKSSSPhosphoSitePlus
S376QVSLTsKKHSRPhosphoSitePlus
S383KHSRKsSSYSSPhosphoSitePlus
Y397TVKTSy_____PhosphoSitePlus
Y386RKSSSySSSSTPhosphoSitePlus
S390SYSSSsTTVKTPhosphoSitePlus

Dephosphorylation site
PAR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296677C226SCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
PAR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PAR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
THRB_HUMANPAR2_HUMANligand -> receptorHPMR
PAR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNAI3_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNAI2_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNA11_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNAQ_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05143African trypanosomiasis
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030193regulation of blood coagulationIDAbiological_process
GO:0070661leukocyte proliferationIEAbiological_process
GO:0043311positive regulation of eosinophil degranulationIDAbiological_process
GO:0050921positive regulation of chemotaxisIEAbiological_process
GO:0030836positive regulation of actin filament depolymerizaIDAbiological_process
GO:0010804negative regulation of tumor necrosis factor-mediaIDAbiological_process
GO:0031681G-protein beta-subunit bindingIEAmolecular_function
GO:0015057thrombin receptor activityIEAmolecular_function
GO:0004930G-protein coupled receptor activityISSmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0090195chemokine secretionIEAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:2000484positive regulation of interleukin-8 secretionIDAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0034140negative regulation of toll-like receptor 3 signalIMPbiological_process
GO:0090198negative regulation of chemokine secretionIDAbiological_process
GO:0050900leukocyte migrationIDAbiological_process
GO:0042119neutrophil activationIDAbiological_process
GO:2000778positive regulation of interleukin-6 secretionIDAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0031274positive regulation of pseudopodium assemblyIEAbiological_process
GO:0031143pseudopodiumIEAcellular_component
GO:0046330positive regulation of JNK cascadeIDAbiological_process
GO:0002741positive regulation of cytokine secretion involvedIDAbiological_process
GO:0007596blood coagulationIEAbiological_process
GO:0046329negative regulation of JNK cascadeIDAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0060100positive regulation of phagocytosis, engulfmentIDAbiological_process
GO:0035025positive regulation of Rho protein signal transducIEAbiological_process
GO:0005794Golgi apparatusTAScellular_component
GO:0003104positive regulation of glomerular filtrationIEAbiological_process
GO:0072643interferon-gamma secretionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034145positive regulation of toll-like receptor 4 signalIDAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0034141positive regulation of toll-like receptor 3 signalIMPbiological_process
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeIDAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0034137positive regulation of toll-like receptor 2 signalIMPbiological_process
GO:0070963positive regulation of neutrophil mediated killingIDAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:1900135positive regulation of renin secretion into blood IEAbiological_process
GO:0002690positive regulation of leukocyte chemotaxisIDAbiological_process
GO:0002286T cell activation involved in immune responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0061028establishment of endothelial barrierIDAbiological_process
GO:0050702interleukin-1 beta secretionIDAbiological_process
GO:0032930positive regulation of superoxide anion generationIDAbiological_process
GO:0035926chemokine (C-C motif) ligand 2 secretionIDAbiological_process
GO:0072608interleukin-10 secretionIDAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0046328regulation of JNK cascadeIDAbiological_process
GO:0097029mature dendritic cell differentiationIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0050927positive regulation of positive chemotaxisIDAbiological_process
GO:0006954inflammatory responseIEAbiological_process