Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAI1_HUMAN
Description:serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Source:HGNC Symbol;Acc:8583]
Location:chr7 q22.1
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y193LVNALyFNGQWSerpinPhosphoSitePlus
T200NGQWKtPFPDSSerpinPhosphoSitePlus

Dephosphorylation site
PAI1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000223095A119VTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000223095Lung CancerCancer vs. Cancercell lineDown17284061
ENSP00000223095Breast CancerNormal vs. Cancercell lineDown0.09120052998
ENSP00000223095Breast CancerNormal vs. Cancercell lineDown0.1120052998
ENSP00000223095Breast CancerMetastasiscell lineUp1.320052998
ENSP00000223095Ovarian CancerMetastasiscell lineDown0.1517892554
ENSP00000223095Ovarian CancerMetastasiscell lineDown17892554
ENSP00000223095Gastric CancerNormal vs. Cancercell lineDown0.0820812763
ENSP00000223095Gastric CancerNormal vs. Cancercell lineDown0.0520812763

Hyperphosphorylation site
PAI1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PAI1_HUMANLRP1_HUMANligand -> receptorHPMR
P53_HUMANPAI1_HUMANTF -> target geneKEGG
HLTF_HUMANPAI1_HUMANTF -> target geneTRANSFAC
SMAD4_HUMANPAI1_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANPAI1_HUMANTF -> target geneTRANSFAC
TFE3_HUMANPAI1_HUMANTF -> target geneTRANSFAC
BMAL1_HUMANPAI1_HUMANTF -> target geneTRANSFAC
BMAL2_HUMANPAI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04115p53 signaling pathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0001300chronological cell agingIEPbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0050829defense response to Gram-negative bacteriumIGIbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0070887cellular response to chemical stimulusIMPbiological_process
GO:0032757positive regulation of interleukin-8 productionIMPbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0004867serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0048260positive regulation of receptor-mediated endocytosIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0030195negative regulation of blood coagulationICbiological_process
GO:0010469regulation of receptor activityIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0030168platelet activationTASbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0035491positive regulation of leukotriene production invoIMPbiological_process
GO:0030194positive regulation of blood coagulationIMPbiological_process
GO:0005576extracellular regionIDAcellular_component
GO:0033629negative regulation of cell adhesion mediated by iIDAbiological_process
GO:0030336negative regulation of cell migrationIDAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0051918negative regulation of fibrinolysisIDAbiological_process
GO:2000098negative regulation of smooth muscle cell-matrix aIDAbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0061044negative regulation of vascular wound healingIGIbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0001525angiogenesisIEPbiological_process
GO:0061045negative regulation of wound healingICbiological_process
GO:0010757negative regulation of plasminogen activationIMPbiological_process
GO:0090026positive regulation of monocyte chemotaxisIMPbiological_process
GO:0071222cellular response to lipopolysaccharideIMPbiological_process
GO:0014912negative regulation of smooth muscle cell migratioIDAbiological_process
GO:0010951negative regulation of endopeptidase activityIDAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0042730fibrinolysisTASbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0050729positive regulation of inflammatory responseIGIbiological_process