| UniProt/SwissProt ID: | BMAL2_HUMAN |
| Description: | aryl hydrocarbon receptor nuclear translocator-like 2 [Source:HGNC Symbol;Acc:18984] |
| Location: | chr12 p11.23 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S208 | KILFVsKSVSK | PAS | PhosphoSitePlus |
| S212 | VSKSVsKILNY | PAS | PhosphoSitePlus |
| S539 | SYLDDsSPTGL | PhosphoSitePlus | |
| S245 | KEQLSsFDISP | PhosphoSitePlus | |
| S540 | YLDDSsPTGLM | PhosphoSitePlus | |
| S210 | LFVSKsVSKIL | PAS | PhosphoSitePlus |
| T148 | KLDKLtVLRMA | HLH | PhosphoSitePlus |
| Dephosphorylation site |
| BMAL2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000266503 | W323R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000266503 | I372L | COSMIC | Melanoma | 21499247 | ENSP00000379238 | M86I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000266503 | M123I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000312247 | M109I | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| BMAL2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BMAL2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BMAL2_HUMAN | PAI1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| BMAL2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | NAS | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0007623 | circadian rhythm | IDA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0009649 | entrainment of circadian clock | NAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0000982 | RNA polymerase II core promoter proximal region se | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |