| UniProt/SwissProt ID: | MOES_HUMAN |
| Description: | moesin [Source:HGNC Symbol;Acc:7373] |
| Location: | chrX q12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T558 | RDKYKtLRQIR | PRKCQ | HPRD |
| S527 | LKALTsELANA | HPRD; SysPTM | |
| T558 | RDKYKtLRQIR | PKCt(PKC theta | RegPhos |
| S407 | ALLQAsRDQKK | HPRD | |
| Y291 | GNHELyMRRRK | FERM_C | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | ROCK1 | HPRD; RegPhos |
| S429 | LTARIsQLEMA | ERM | PhosphoSitePlus |
| Y116 | LNDDIyCPPET | RegPhos | |
| Y228 | LGLNIyEQNDR | FERM_C | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | phosphoELM; RegPhos | |
| T465 | RAELKtAMSTP | ERM | PhosphoSitePlus |
| T465 | RAELKtAMSTP | HPRD | |
| Y270 | PDFVFyAPRLR | FERM_C | PhosphoSitePlus |
| S468 | LKTAMsTPHVA | ERM | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | ROCK_group | phosphoELM; RegPhos |
| T66 | LNKKVtAQDVR | FERM_N | PhosphoSitePlus |
| Y116 | LNDDIyCPPET | FERM_M | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | PKCt | RegPhos |
| T558 | RDKYKtLRQIR | ERM | PhosphoSitePlus |
| Y556 | LGRDKyKTLRQ | ERM | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | PKA_group | phosphoELM; RegPhos |
| S576 | IDEFEsM____ | ERM | PhosphoSitePlus; SysPTM |
| S74 | DVRKEsPLLFK | FERM_N | PhosphoSitePlus |
| T469 | KTAMStPHVAE | ERM | PhosphoSitePlus |
| S576 | IDEFEsM | RegPhos; SysPTM | |
| T558 | RDKYKtLRQIR | LOK | phosphoELM |
| S407 | ALLQAsRDQKK | ERM | PhosphoSitePlus |
| T98 | LIQDItQRLFF | FERM_M | PhosphoSitePlus |
| T4 | __MPKtISVRV | PhosphoSitePlus | |
| T425 | EMAELtARISQ | ERM | PhosphoSitePlus |
| S576 | IDEFE | HPRD; SysPTM | |
| S468 | LKTAMsTPHVA | HPRD | |
| T57 | TKGFStWLKLN | FERM_N | PhosphoSitePlus |
| T413 | RDQKKtQEQLA | ERM | PhosphoSitePlus |
| T558 | RDKYKtLRQIR | LRRK2 | phosphoELM |
| T469 | KTAMStPHVAE | HPRD | |
| S384 | RKRAQsEAEKL | ERM | PhosphoSitePlus |
| Y146 | VHKSGyLAGDK | FERM_M | PhosphoSitePlus |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T558 | LGRDKYKtLRQIRQG | PPM1A | HPRD |
| T558 | LGRDKYKtLRQIRQG | PPM1B | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353408 | K448N | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000353408 | D88A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353408 | D88A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353408 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.036 | 18646787 | ENSP00000353408 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.5 | 18646787 | ENSP00000353408 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000353408 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 2 | 16788983 | ENSP00000353408 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 5.4 | 18665625 | ENSP00000353408 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 2.5 | 18665625 | ENSP00000353408 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.22 | 19142970 | ENSP00000353408 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.23 | 19142970 | ENSP00000353408 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.49 | 19142970 | ENSP00000353408 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000353408 | Breast Cancer | Metastasis | tissue | Down | 18257521 | ENSP00000353408 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 4.1 | 19120023 | ENSP00000353408 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000353408 | Gastric Cancer | Treatment (none vs. 5-fluorouracil treatment) | cell line | Up | 3.9 | 16900703 | ENSP00000353408 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.46 | 19330469 | ENSP00000353408 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.33 | 20052998 | ENSP00000353408 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.9 | 20052998 | ENSP00000353408 | Breast Cancer | Metastasis | cell line | Up | 6 | 20052998 | ENSP00000353408 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.43 | 20052998 | ENSP00000353408 | Breast Cancer | Normal vs. Cancer | cell line | Up | 3.5 | 20052998 | ENSP00000353408 | Breast Cancer | Metastasis | cell line | Up | 8.5 | 20052998 | ENSP00000353408 | Nonmelanoma | Normal vs. Cancer | cell line | Down | 0.62 | 19243805 | ENSP00000353408 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000353408 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 3 | 19199705 |
| Hyperphosphorylation site |
| MOES_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCT_HUMAN | MOES_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ROCK1_HUMAN | MOES_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | MOES_HUMAN | kinase -> substrate | RegPhos |
| YES_HUMAN | MOES_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PPM1A_HUMAN | MOES_HUMAN | phosphatase -> substrate | HPRD |
| PPM1B_HUMAN | MOES_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| hsa05162 | Measles |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001931 | uropod | IEA | cellular_component |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0022614 | membrane to membrane docking | IEP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0016323 | basolateral plasma membrane | IEA | cellular_component |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0030175 | filopodium | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0050839 | cell adhesion molecule binding | IPI | molecular_function |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0008092 | cytoskeletal protein binding | IEA | molecular_function |
| GO:0045177 | apical part of cell | IDA | cellular_component |
| GO:0019898 | extrinsic to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005856 | cytoskeleton | TAS | cellular_component |
| GO:2000401 | regulation of lymphocyte migration | IMP | biological_process |
| GO:0031528 | microvillus membrane | IEA | cellular_component |
| GO:0007159 | leukocyte cell-cell adhesion | IEP | biological_process |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0005902 | microvillus | IDA | cellular_component |
| GO:0050900 | leukocyte migration | IEP | biological_process |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0019901 | protein kinase binding | IPI | molecular_function |