Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TFAP4_HUMAN
Description:transcription factor AP-4 (activating enhancer binding protein 4) [Source:HGNC Symbol;Acc:11745]
Location:chr16 p13.3
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T282QHIEGtQEKQEPhosphoSitePlus
T8YFMVPtQKVPSHPRD
T37ANIPLtPETQRPhosphoSitePlus
S123QELSGsSPKRRPhosphoSitePlus; HPRD
Y3___MEyFMVPTPhosphoSitePlus
S121FIQELsGSSPKPhosphoSitePlus
S124ELSGSsPKRRRPhosphoSitePlus; HPRD; phosphoELM
S139DEGIGsPDIWEPhosphoSitePlus; HPRD; phosphoELM
S13TQKVPsLQHFRPhosphoSitePlus; HPRD
Y3MVPTHPRD

Dephosphorylation site
TFAP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000204517R47QCOSMICOvarian Cancer21720365
ENSP00000204517E21KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TFAP4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TFAP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TFAP4_HUMANMT2_HUMANTF -> target geneTRANSFAC
TFAP4_HUMANMLTK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TFAP4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043392negative regulation of DNA bindingIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0006461protein complex assemblyIEAbiological_process
GO:0071157negative regulation of cell cycle arrestIMPbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0070888E-box bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0043923positive regulation by host of viral transcriptionIDAbiological_process
GO:0043922negative regulation by host of viral transcriptionIDAbiological_process
GO:0045736negative regulation of cyclin-dependent protein kiIDAbiological_process
GO:0042826histone deacetylase bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0071549cellular response to dexamethasone stimulusIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0007090regulation of S phase of mitotic cell cycleIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0003677DNA bindingIDAmolecular_function


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