Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MKNK2_HUMAN
Description:MAP kinase interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:7111]
Location:chr19 p13.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T379ENTLPtPMVLQHPRD
S437RCLQLsPPSQSHPRD
S15QGFHRsFKGQNPhosphoSitePlus
S76ATDSFsGRFEDPhosphoSitePlus
S440QLSPPsQSKLAHPRD
S220HPNQVsPVKICHPRD
S27FELAFsLDQPDHPRD
T72KRGRAtDSFSGPhosphoSitePlus
S452RRQRAsLSSAPPhosphoSitePlus; HPRD; SysPTM
S74GRATDsFSGRFPhosphoSitePlus; HPRD; phosphoELM
S454QRASLsSAPVVHPRD

Dephosphorylation site
MKNK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000250896D228NCOSMICBreast Cancer20668451
ENSP00000250896K390*Ding2008, COSMICLung Cancer18948947
ENSP00000250896F149LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MKNK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MKNK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MKNK2_HUMANSMAD6_HUMANkinase -> substrateRobert H Newman (2013)
MKNK2_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
MKNK2_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
MKNK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANMKNK2_HUMANkinase -> substrateKEGG
MKNK2_HUMANIF4E_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
MKNK2_HUMANATF4_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0071243cellular response to arsenic-containing substanceIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0030097hemopoiesisIDAbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0016020membraneIEAcellular_component


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