Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KSR2_HUMAN
Description:kinase suppressor of ras 2 [Source:HGNC Symbol;Acc:18610]
Location:chr12 q24.23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S294GTPPPsSRKLIC1_1PhosphoSitePlus
T269TPNIVtTVTPPPhosphoSitePlus
T260RHAVRtPPRTPPhosphoSitePlus
S34NMIDLsISNLEPhosphoSitePlus
Y566LPASHyYKYKQPkinasePhosphoSitePlus
S394SANTLsVPRWSPhosphoSitePlus
T264RTPPRtPNIVTPhosphoSitePlus
S474LVRTEsVPCDIPhosphoSitePlus
S474LVRTEsVPCDIMARK3RegPhos
S399SVPRWsPQIPRPhosphoSitePlus
T276VTPPGtPPMRKPhosphoSitePlus
T497LHISQtLPKTNPhosphoSitePlus
T272IVTTVtPPGTPPhosphoSitePlus
S311TALHRsKSHEFC1_1PhosphoSitePlus
T306LIPGFtALHRSC1_1PhosphoSitePlus
S939RNRRLsHPGHFPhosphoSitePlus
S490KPPRYsDLHISPhosphoSitePlus
T290LKPPGtPPPSSPhosphoSitePlus
T270PNIVTtVTPPGPhosphoSitePlus

Dephosphorylation site
KSR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339952R676SHPILung Cancer17344846

Differential expressed protein
KSR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KSR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MARK3_HUMANKSR2_HUMANkinase -> substrateRegPhos
KSR2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KSR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035556intracellular signal transductionIEAbiological_process
GO:0019722calcium-mediated signalingIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0005078MAP-kinase scaffold activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0043410positive regulation of MAPK cascadeIEAbiological_process


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