Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MARK3_HUMAN
Description:MAP/microtubule affinity-regulating kinase 3 [Source:HGNC Symbol;Acc:6897]
Location:chr14 q32.32
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y508TRRNTyVCSERPhosphoSitePlus
Y690ANNCDyEQRERPhosphoSitePlus
T234GGKLDtFCGSPphosphoELM; RegPhos
S469GIAPAsPMLGNPhosphoSitePlus; HPRD
S490ERKKSsTVPSSPhosphoSitePlus
Y340MVGMGySQEEIUBAPhosphoSitePlus
S341VGMGYsQEEIQUBAPhosphoSitePlus
S643SSRNVsAEQKDPhosphoSitePlus
S568STHSIsSAATPphosphoELM
S376LDASDsSSSSNPhosphoSitePlus
S618TRRNMsFRFIKPhosphoSitePlus
S455ISSRKsSGSAVPhosphoSitePlus; HPRD
T438PKRSQtSTADSPhosphoSitePlus
S657EAKPRsLRFTWPhosphoSitePlus
S442KQRRYsDHAGPphosphoELM; RegPhos; SysPTM
S400NSTGQsPHHKVPhosphoSitePlus; HPRD
S546THSISsAATPDPhosphoSitePlus
S492GIAPAsPMLGNphosphoELM; RegPhos; SysPTM
T397DLNNStGQSPHPhosphoSitePlus; HPRD
S563RTPVAsTHSISphosphoELM
T576ERRTAtYNGPPPhosphoSitePlus
T614LSHEAtPLSQTphosphoELM
S587ASPSLsHEATPPhosphoSitePlus; HPRD
T491RKKSStVPSSNPhosphoSitePlus
T564TASRStFHGQPPhosphoSitePlus
T536IPDQRtPVASTPhosphoSitePlus; HPRD
S42ARCRNsIASCAPhosphoSitePlus; HPRD
T591LSHEAtPLSQTPhosphoSitePlus
S608PPASPsLSHEAphosphoELM
S419KQRRYsDHAGPPhosphoSitePlus; HPRD
T564TPVAStHSISSphosphoELM
S494SSTVPsSNTASPhosphoSitePlus; HPRD
T549ISSAAtPDRIRPhosphoSitePlus; HPRD
T572ISSAAtPDRIRphosphoELM
S598LSQTRsRGSTNPhosphoSitePlus; HPRD
S215DTFCGsPPYAAPkinasePhosphoSitePlus
T211GGKLDtFCGSPPkinasePhosphoSitePlus
T3___MStRTPLPPhosphoSitePlus
S601TRSRGsTNLFSPhosphoSitePlus; HPRD
T61YRLLKtIGKGNPkinasePhosphoSitePlus
S383SSSNLsLAKVRPhosphoSitePlus; HPRD
S540RTPVAsTHSISPhosphoSitePlus
Y432PSVVAyPKRSQPhosphoSitePlus
S499SSNTAsGGMTRPhosphoSitePlus
S745FKNIAsKIANEKA1PhosphoSitePlus
T234GGKLDtFCGSPLKB1(STK11RegPhos
Y418QKQRRySDHAGPhosphoSitePlus; HPRD
S391KVRPSsDLNNSHPRD
S545STHSIsSAATPPhosphoSitePlus
S377DASDSsSSSNLPhosphoSitePlus; HPRD
T234GGKLDtFCGSPLKB1phosphoELM
S374SELDAsDSSSSPhosphoSitePlus; HPRD
S238DTFCGsPPYAAphosphoELM; RegPhos; SysPTM
S380DSSSSsNLSLAPhosphoSitePlus; HPRD
S585PPASPsLSHEAPhosphoSitePlus; HPRD
T541TPVAStHSISSPhosphoSitePlus
Y577RRTATyNGPPAPhosphoSitePlus
S619RSRNVsAEQKDHPRD
S511NTYVCsERTTAPhosphoSitePlus
S543VASTHsISSAAPhosphoSitePlus
T530MTRRNtYVCSEphosphoELM
S379SDSSSsSNLSLPhosphoSitePlus
S378ASDSSsSSNLSPhosphoSitePlus
T507MTRRNtYVCSEPhosphoSitePlus
S566VASTHsISSAAphosphoELM
S476MLGNAsNPNKAPhosphoSitePlus; HPRD
S624TRSRGsTNLFSphosphoELM; RegPhos
T61YRLLKtIGKGNHPRD
S606NGPPAsPSLSHphosphoELM
T503ASGGMtRRNTYPhosphoSitePlus
S583NGPPAsPSLSHPhosphoSitePlus; HPRD
S610ASPSLsHEATPphosphoELM
S489PERKKsSTVPSPhosphoSitePlus

Dephosphorylation site
MARK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303698E344KBIOMARTBreast Cancer21930507, 21930502
ENSP00000216288E344KBIOMARTBreast Cancer21930507, 21930502
ENSP00000408092E367KBIOMARTBreast Cancer21930507, 21930502
ENSP00000411397E120KTCGAOvarian Cancer21720365, 18772890
ENSP00000411397E344KBIOMARTBreast Cancer21930507, 21930502
ENSP00000402104E265KBIOMARTBreast Cancer21930507, 21930502
ENSP00000303698*730YCOSMICLung Cancer18948947

Differential expressed protein
MARK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MARK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MARK3_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
MARK3_HUMANCHK2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMARK3_HUMANkinase -> substrateRegPhos
STK11_HUMANMARK3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MARK3_HUMANMID51_HUMANkinase -> substrateRobert H Newman (2013)
MARK3_HUMANKSR1_HUMANkinase -> substrateRegPhos
MARK3_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
MARK3_HUMANKSR2_HUMANkinase -> substrateRegPhos
MARK3_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MARK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23