| UniProt/SwissProt ID: | DKK2_HUMAN |
| Description: | dickkopf 2 homolog (Xenopus laevis) [Source:HGNC Symbol;Acc:2892] |
| Location: | chr4 q25 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y155 | RNHGHySNHDL | PhosphoSitePlus | |
| S97 | SPHQGsSACMV | Dickkopf_N | PhosphoSitePlus |
| S156 | NHGHYsNHDLG | PhosphoSitePlus | |
| S92 | GRYCHsPHQGS | Dickkopf_N | PhosphoSitePlus |
| Y89 | CEVGRyCHSPH | Dickkopf_N | PhosphoSitePlus |
| S98 | PHQGSsACMVC | Dickkopf_N | PhosphoSitePlus |
| Dephosphorylation site |
| DKK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000285311 | G221D | COSMIC | Lung Cancer | ENSP00000285311 | R112G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000285311 | C127S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000285311 | L253F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000285311 | S222F | COSMIC | Melanoma | ENSP00000285311 | V241I | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DKK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DKK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DKK2_HUMAN | LRP6_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000981 | sequence-specific DNA binding RNA polymerase II tr | IEA | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0030178 | negative regulation of Wnt receptor signaling path | IEA | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0090263 | positive regulation of canonical Wnt receptor sign | IDA | biological_process |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |