| UniProt/SwissProt ID: | KHDR1_HUMAN |
| Description: | KH domain containing, RNA binding, signal transduction associated 1 [Source:HGNC Symbol;Acc:18116] |
| Location: | chr1 p35.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T374 | YGYDDtYAEQS | PhosphoSitePlus | |
| S18 | RSSGRsGSMDP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T84 | GGPAPtPLLPP | p38a(MAPK14 | RegPhos |
| S388 | YEGYYsQSQGD | PhosphoSitePlus | |
| S58 | GGARAsPATQP | Erk2 | RegPhos |
| Y440 | YREHPyG | PTK6 | HPRD |
| Y397 | GDSEYyDYGHG | PhosphoSitePlus | |
| S24 | GSMDPsGAHPS | PhosphoSitePlus | |
| S58 | GGARAsPATQP | p38a(MAPK14 | RegPhos |
| T84 | GGPAPtPLLPP | MAPK1 | HPRD |
| Y380 | YAEQSyEGYEG | PhosphoSitePlus | |
| Y371 | YEEYGyDDTYA | PhosphoSitePlus | |
| Y387 | GYEGYySQSQG | PhosphoSitePlus | |
| T365 | PPAPEtYEEYG | PhosphoSitePlus | |
| Y440 | YREHPyGRY__ | PhosphoSitePlus | |
| S196 | TGAKIsVLGKG | PhosphoSitePlus | |
| T33 | PSVRQtPSRQP | PhosphoSitePlus; HPRD; RegPhos | |
| Y366 | PAPETyEEYGY | PhosphoSitePlus | |
| T317 | ALVRGtPVRGA | PhosphoSitePlus | |
| T77 | TGPDAtVGGPA | PhosphoSitePlus | |
| S58 | GGARAsPATQP | PhosphoSitePlus | |
| Y411 | DSYEAyGQDDW | PhosphoSitePlus | |
| T84 | GGPAPtPLLPP | PhosphoSitePlus | |
| S35 | VRQTPsRQPPL | PhosphoSitePlus; HPRD | |
| T61 | RASPAtQPPPL | PhosphoSitePlus; HPRD; phosphoELM | |
| T317 | ALVRGtPVRGA | CDK1 | HPRD; phosphoELM |
| S58 | GGARAsPATQP | MAPK14 | phosphoELM |
| Y103 | EPENKyLPELM | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y375 | GYDDTyAEQSY | PhosphoSitePlus | |
| Y443 | HPYGRy_____ | PhosphoSitePlus | |
| Y435 | PVKGAyREHPY | PhosphoSitePlus | |
| Y443 | HPYGRy | BRK | RegPhos |
| Y435 | PVKGAyREHPY | PTK6 | HPRD |
| Y408 | EVQDSyEAYGQ | PhosphoSitePlus | |
| T349 | APRARtAGIQR | HPRD | |
| S70 | PLLPPsATGPD | HPRD | |
| T317 | ALVRGtPVRGA | CDC2 | RegPhos |
| Y440 | YREHPyGRY | BRK | RegPhos |
| T317 | ALVRGtPVRGA | CDC2(CDK1 | RegPhos |
| T72 | LPPSAtGPDAT | PhosphoSitePlus; HPRD | |
| Y396 | QGDSEyYDYGH | PhosphoSitePlus | |
| S15 | RMSRSsGRSGS | PhosphoSitePlus; HPRD; phosphoELM | |
| T92 | LPPSAtASVKM | HPRD | |
| Y443 | HPYG | PTK6 | HPRD |
| S58 | GGARAsPATQP | MAPK1 | HPRD |
| Y369 | ETYEEyGYDDT | PhosphoSitePlus | |
| S20 | SGRSGsMDPSG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T84 | GGPAPtPLLPP | MAPK14 | phosphoELM |
| S202 | VLGKGsMRDKA | PhosphoSitePlus; HPRD | |
| T84 | GGPAPtPLLPP | Erk2 | RegPhos |
| Y435 | PVKGAyREHPY | BRK | RegPhos |
| S14 | ARMSRsSGRSG | HPRD | |
| S29 | SGAHPsVRQTP | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| KHDR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000313829 | E384K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000313829 | E384K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000313829 | Hepatocellular Carcinoma | Treatment (none vs resveratrol-treatment) | cell line | Up | 19996131 | |
| Hyperphosphorylation site |
| KHDR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCT_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BLK_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | KHDR1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CDK4_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK14_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR2_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ARAF_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | KHDR1_HUMAN | kinase -> substrate | RegPhos |
| WEE1_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | KHDR1_HUMAN | kinase -> substrate | HPRD |
| PTK6_HUMAN | KHDR1_HUMAN | kinase -> substrate | RegPhos |
| PAK4_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KHDR1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070618 | Grb2-Sos complex | IEA | cellular_component |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0046831 | regulation of RNA export from nucleus | IEA | biological_process |
| GO:0046831 | regulation of RNA export from nucleus | ISS | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | ISS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | ISS | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | IEA | molecular_function |
| GO:0045948 | positive regulation of translational initiation | IDA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IDA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | IPI | molecular_function |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0046833 | positive regulation of RNA export from nucleus | IDA | biological_process |