Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAK3_HUMAN
Description:Janus kinase 3 [Source:HGNC Symbol;Acc:6193]
Location:chr19 p13.11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y981LDKDYyVVREPPkinase_TyrPhosphoSitePlus
T8PPSEEtPLIPQRegPhos
Y785LISSDyELLSDPhosphoSitePlus; phosphoELM; RegPhos
Y785LISSDyELLSDJAK3HPRD; phosphoELM; RegPhos
T391INKLKtGGSRPSH2PhosphoSitePlus
S15LIPQRsCSLLSPhosphoSitePlus
S568KNCMEsFLEAAPkinase_TyrPhosphoSitePlus
Y980PLDKDyYVVREautocatalysisRegPhos
Y980PLDKDyYVVREJAK3HPRD; phosphoELM; RegPhos
Y980PLDKDyYVVREPkinase_TyrPhosphoSitePlus
S398GSRPGsYVLRRSH2PhosphoSitePlus
S498SPPTSsLVQPQPhosphoSitePlus
S17PQRSCsLLSTEPhosphoSitePlus
S5_MAPPsEETPLPhosphoSitePlus
S782LNSLIsSDYELPhosphoSitePlus
Y506QPQSQyQLSQMPhosphoSitePlus
Y904RLVMEyLPSGCPkinase_TyrPhosphoSitePlus
Y939CKGMEyLGSRRPkinase_TyrPhosphoSitePlus
Y981LDKDYyVVREPJAK3HPRD; phosphoELM; RegPhos

Dephosphorylation site
JAK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000391676L527PHPIGastric Cancer17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000391676Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp416319398

Hyperphosphorylation site
JAK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANJAK3_HUMANkinase -> substrateRegPhos
JAK3_HUMANJAK1_HUMANkinase -> substrateRegPhos; NetPath
JAK3_HUMANSTAT3_HUMANkinase -> substrateNetPath
JAK3_HUMANFES_HUMANkinase -> substrateNetPath
JAK3_HUMANSTA5A_HUMANkinase -> substrateNetPath
JAK3_HUMANJAK3_HUMANkinase -> substrateNetPath
JAK3_HUMANSOCS3_HUMANkinase -> substrateNetPath
JAK3_HUMANSIG10_HUMANkinase -> substrateRegPhos
JAK3_HUMANIRS2_HUMANkinase -> substrateNetPath
JAK3_HUMANIRS1_HUMANkinase -> substrateNetPath
JAK3_HUMANSTAM1_HUMANkinase -> substrateNetPath
PTN6_HUMANJAK3_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa05169Epstein-Barr virus infection
hsa05166HTLV-I infection
hsa04062Chemokine signaling pathway
hsa05203Viral carcinogenesis
hsa04630Jak-STAT signaling pathway
hsa05340Primary immunodeficiency

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045221negative regulation of FasL biosynthetic processISSbiological_process
GO:0070244negative regulation of thymocyte apoptotic processISSbiological_process
GO:0007260tyrosine phosphorylation of STAT proteinTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0030183B cell differentiationISSbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0070669response to interleukin-2TASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0045626negative regulation of T-helper 1 cell differentiaISSbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0045626negative regulation of T-helper 1 cell differentiaIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityISSmolecular_function
GO:0045221negative regulation of FasL biosynthetic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070232regulation of T cell apoptotic processISSbiological_process
GO:0018108peptidyl-tyrosine phosphorylationISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0043029T cell homeostasisIEAbiological_process
GO:0032695negative regulation of interleukin-12 productionIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:0007262STAT protein import into nucleusTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0070244negative regulation of thymocyte apoptotic processIEAbiological_process
GO:0032695negative regulation of interleukin-12 productionISSbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0050868negative regulation of T cell activationIEAbiological_process
GO:0070670response to interleukin-4IDAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0002731negative regulation of dendritic cell cytokine proIEAbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayISSbiological_process
GO:0032693negative regulation of interleukin-10 productionISSbiological_process
GO:0050868negative regulation of T cell activationISSbiological_process
GO:0042981regulation of apoptotic processISSbiological_process
GO:0071104response to interleukin-9TASbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0035771interleukin-4-mediated signaling pathwayIDAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0032693negative regulation of interleukin-10 productionIEAbiological_process
GO:0043029T cell homeostasisISSbiological_process
GO:0070672response to interleukin-15TASbiological_process
GO:0002731negative regulation of dendritic cell cytokine proISSbiological_process
GO:0070232regulation of T cell apoptotic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function