Phosphorylation

Source	Target	Relationship	Resource
IL1B_HUMAN	IL1R1_HUMAN	ligand -> receptor	HPMR
IL1B_HUMAN	IL1R2_HUMAN	ligand -> receptor	HPMR
FOS_HUMAN	IL1B_HUMAN	other	KEGG
NFKB1_HUMAN	IL1B_HUMAN	other	KEGG
IRF5_HUMAN	IL1B_HUMAN	other	KEGG
SPI1_HUMAN	IL1B_HUMAN	TF -> target gene	TRANSFAC
CEBPB_HUMAN	IL1B_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05332	Graft-versus-host disease
hsa04620	Toll-like receptor signaling pathway
hsa04640	Hematopoietic cell lineage
hsa05140	Leishmaniasis
hsa05132	Salmonella infection
hsa04064	NF-kappa B signaling pathway
hsa05152	Tuberculosis
hsa04010	MAPK signaling pathway
hsa05142	Chagas disease (American trypanosomiasis)
hsa05134	Legionellosis
hsa04621	NOD-like receptor signaling pathway
hsa04210	Apoptosis
hsa05144	Malaria
hsa04380	Osteoclast differentiation
hsa04060	Cytokine-cytokine receptor interaction
hsa05010	Alzheimer's disease
hsa05164	Influenza A
hsa05146	Amoebiasis
hsa05162	Measles
hsa05323	Rheumatoid arthritis
hsa04623	Cytosolic DNA-sensing pathway
hsa04940	Type I diabetes mellitus
hsa05133	Pertussis
hsa05020	Prion diseases
hsa05168	Herpes simplex infection
hsa05143	African trypanosomiasis

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0010829	negative regulation of glucose transport	IEA	biological_process
GO:0051091	positive regulation of sequence-specific DNA bindi	IDA	biological_process
GO:0050995	negative regulation of lipid catabolic process	IDA	biological_process
GO:0033198	response to ATP	IEA	biological_process
GO:0005615	extracellular space	IEA	cellular_component
GO:0014805	smooth muscle adaptation	NAS	biological_process
GO:0010575	positive regulation vascular endothelial growth fa	IEA	biological_process
GO:0046827	positive regulation of protein export from nucleus	NAS	biological_process
GO:0030593	neutrophil chemotaxis	IEA	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	biological_process
GO:0046330	positive regulation of JNK cascade	IEA	biological_process
GO:0002711	positive regulation of T cell mediated immunity	IC	biological_process
GO:0032611	interleukin-1 beta production	IEA	biological_process
GO:0035066	positive regulation of histone acetylation	NAS	biological_process
GO:0071310	cellular response to organic substance	IDA	biological_process
GO:0008285	negative regulation of cell proliferation	IDA	biological_process
GO:0005149	interleukin-1 receptor binding	IEA	molecular_function
GO:0043407	negative regulation of MAP kinase activity	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0071407	cellular response to organic cyclic compound	IDA	biological_process
GO:0032308	positive regulation of prostaglandin secretion	IEA	biological_process
GO:0071260	cellular response to mechanical stimulus	IEP	biological_process
GO:0045840	positive regulation of mitosis	IMP	biological_process
GO:0006915	apoptotic process	TAS	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0042102	positive regulation of T cell proliferation	IDA	biological_process
GO:0032496	response to lipopolysaccharide	IEA	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0030730	sequestering of triglyceride	IDA	biological_process
GO:0030141	secretory granule	IEA	cellular_component
GO:0030949	positive regulation of vascular endothelial growth	IC	biological_process
GO:0051092	positive regulation of NF-kappaB transcription fac	IDA	biological_process
GO:0070487	monocyte aggregation	IDA	biological_process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	IDA	biological_process
GO:0031622	positive regulation of fever generation	IEA	biological_process
GO:0045086	positive regulation of interleukin-2 biosynthetic	IMP	biological_process
GO:0060559	positive regulation of calcidiol 1-monooxygenase a	IDA	biological_process
GO:0045080	positive regulation of chemokine biosynthetic proc	IEA	biological_process
GO:0030213	hyaluronan biosynthetic process	IDA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological_process
GO:0000187	activation of MAPK activity	IDA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IDA	biological_process
GO:0008083	growth factor activity	IEA	molecular_function
GO:0019221	cytokine-mediated signaling pathway	IDA	biological_process
GO:0031982	vesicle	IEA	cellular_component
GO:0043491	protein kinase B signaling cascade	IMP	biological_process
GO:0050796	regulation of insulin secretion	IDA	biological_process
GO:0043066	negative regulation of apoptotic process	IDA	biological_process
GO:0032729	positive regulation of interferon-gamma production	IDA	biological_process
GO:0034116	positive regulation of heterotypic cell-cell adhes	IDA	biological_process
GO:0042346	positive regulation of NF-kappaB import into nucle	IDA	biological_process
GO:0045766	positive regulation of angiogenesis	IEA	biological_process
GO:0060355	positive regulation of cell adhesion molecule prod	NAS	biological_process
GO:0033129	positive regulation of histone phosphorylation	NAS	biological_process
GO:0046627	negative regulation of insulin receptor signaling	IEA	biological_process
GO:0032757	positive regulation of interleukin-8 production	IDA	biological_process
GO:0045833	negative regulation of lipid metabolic process	IEA	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB c	IEA	biological_process
GO:0051044	positive regulation of membrane protein ectodomain	IDA	biological_process
GO:0050900	leukocyte migration	IEA	biological_process
GO:0001660	fever generation	IEA	biological_process
GO:0007566	embryo implantation	TAS	biological_process
GO:0019904	protein domain specific binding	IPI	molecular_function
GO:0035690	cellular response to drug	IDA	biological_process
GO:0070164	negative regulation of adiponectin secretion	IEA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0045429	positive regulation of nitric oxide biosynthetic p	IDA	biological_process
GO:0051781	positive regulation of cell division	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0032755	positive regulation of interleukin-6 production	IEA	biological_process
GO:0045410	positive regulation of interleukin-6 biosynthetic	IEA	biological_process
GO:0042221	response to chemical stimulus	IEA	biological_process
GO:0032725	positive regulation of granulocyte macrophage colo	IDA	biological_process
GO:0050996	positive regulation of lipid catabolic process	IEA	biological_process
GO:0005576	extracellular region	NAS	cellular_component
GO:0071639	positive regulation of monocyte chemotactic protei	IDA	biological_process
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0035505	positive regulation of myosin light chain kinase a	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network