| UniProt/SwissProt ID: | IL1R2_HUMAN |
| Description: | interleukin 1 receptor, type II [Source:HGNC Symbol;Acc:5994] |
| Location: | chr2 q11.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S241 | IPVIIsPLKTI | PhosphoSitePlus | |
| T210 | YRCVLtFAHEG | PhosphoSitePlus | |
| T235 | KKKEEtIPVII | PhosphoSitePlus | |
| Dephosphorylation site |
| IL1R2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377066 | R295C | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| IL1R2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL1R2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL1A_HUMAN | IL1R2_HUMAN | ligand -> receptor | HPMR |
| IL1B_HUMAN | IL1R2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| hsa05146 | Amoebiasis |
| hsa04010 | MAPK signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004910 | interleukin-1, Type II, blocking receptor activity | IEA | molecular_function |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004908 | interleukin-1 receptor activity | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |