| UniProt/SwissProt ID: | IF4A2_HUMAN |
| Description: | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:3284] |
| Location: | chr3 q27.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T219 | SATMPtDVLEV | DEAD | PhosphoSitePlus |
| Y251 | GIKQFyINVER | PhosphoSitePlus | |
| S79 | IAQAQsGTGKT | DEAD | PhosphoSitePlus |
| T81 | QAQSGtGKTAT | DEAD | PhosphoSitePlus |
| Y71 | PCIKGyDVIAQ | DEAD | PhosphoSitePlus |
| Y51 | RGIYAyGFEKP | PhosphoSitePlus | |
| T219 | SATMPtDVLEV | HPRD | |
| Y49 | LLRGIyAYGFE | PhosphoSitePlus | |
| Dephosphorylation site |
| IF4A2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000326381 | G3V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000326381 | M316I | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000326381 | V181L | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 |
| Differential expressed protein |
| IF4A2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y49 | ESLLRGIyAYGFEKP | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ILK_HUMAN | IF4A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K4_HUMAN | IF4A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | IF4A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK1_HUMAN | IF4A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | IF4A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| IF4A2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006413 | translational initiation | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deaden | TAS | biological_process |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |
| GO:0006446 | regulation of translational initiation | TAS | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0016281 | eukaryotic translation initiation factor 4F comple | TAS | cellular_component |
| GO:0004386 | helicase activity | TAS | molecular_function |
| GO:0006412 | translation | TAS | biological_process |