| UniProt/SwissProt ID: | KLF11_HUMAN |
| Description: | Kruppel-like factor 11 [Source:HGNC Symbol;Acc:11811] |
| Location: | chr2 p25.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T447 | SRHRRtHTGEK | zf-H2C2_2 | PhosphoSitePlus |
| T83 | SGDVTtTVHMD | PhosphoSitePlus | |
| S124 | TRTPVsPQVTD | PhosphoSitePlus | |
| T82 | DSGDVtTTVHM | PhosphoSitePlus | |
| S150 | VARALsGGAER | PhosphoSitePlus | |
| T449 | HRRTHtGEKKF | zf-H2C2_2 | PhosphoSitePlus |
| T419 | HLRTHtGEKPF | zf-H2C2_2 | PhosphoSitePlus |
| S166 | EPVPSsPCRAK | PhosphoSitePlus | |
| S111 | ITPPQsPDLVE | PhosphoSitePlus | |
| T417 | KAHLRtHTGEK | zf-H2C2_2 | PhosphoSitePlus |
| T73 | RIRPLtPVSDS | PhosphoSitePlus | |
| Dephosphorylation site |
| KLF11_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307023 | C21Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000442722 | C4Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000307023 | K63N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000444690 | C4Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000307023 | Q126* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| KLF11_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KLF11_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KLF11_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| KLF11_HUMAN | HBG2_HUMAN | TF -> target gene | TRANSFAC |
| KLF11_HUMAN | HBE_HUMAN | TF -> target gene | TRANSFAC |
| KLF11_HUMAN | HBG1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KLF11_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0000115 | regulation of transcription involved in S phase of | IDA | biological_process |
| GO:0000981 | sequence-specific DNA binding RNA polymerase II tr | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | IDA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0043065 | positive regulation of apoptotic process | IDA | biological_process |