| UniProt/SwissProt ID: | GRP1_HUMAN |
| Description: | RAS guanyl releasing protein 1 (calcium and DAG-regulated) [Source:HGNC Symbol;Acc:9878] |
| Location: | chr15 q14 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S491 | QDGYIsQEEFE | efhand | PhosphoSitePlus |
| Y215 | SEHLTyLEFKS | RasGEF | PhosphoSitePlus |
| S694 | PFVLSsPRKTA | PhosphoSitePlus | |
| S198 | KKRKVsLLFDH | PhosphoSitePlus | |
| S732 | WENKDsLIKSK | PhosphoSitePlus | |
| S661 | SSQKIsLRLKR | PhosphoSitePlus | |
| T45 | SLAHItQFRMM | PhosphoSitePlus | |
| T184 | WSRKLtQRIKS | PhosphoSitePlus | |
| S657 | LMGVSsQKISL | PhosphoSitePlus | |
| S210 | EPEELsEHLTY | RasGEF | PhosphoSitePlus |
| Dephosphorylation site |
| GRP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000310244 | P34L | COSMIC | Intestines Cancer | 17932254 | ENSP00000310244 | F226L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000310244 | S314L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000310244 | G654fs*11 | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| GRP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PLCG1_HUMAN | GRP1_HUMAN | other | KEGG |
| GRP1_HUMAN | RRAS2_HUMAN | other | KEGG |
| SOS1_HUMAN | GRP1_HUMAN | other | KEGG |
| IKKA_HUMAN | GRP1_HUMAN | other | KEGG |
| GRP1_HUMAN | RASH_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04660 | T cell receptor signaling pathway |
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0008289 | lipid binding | TAS | molecular_function |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | molecular_function |