Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRM5_HUMAN
Description:glutamate receptor, metabotropic 5 [Source:HGNC Symbol;Acc:4597]
Location:chr11 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T607IIYRDtPVVKS7tm_3PhosphoSitePlus
T841AFTTStVVRMHPRKCAHPRD
S840SAFTTsTVVRMPRKCZHPRD
S840SAFTTsTVVRMPRKCGHPRD
S840SAFTTsTVVRMPRKCDHPRD
S840SAFTTsTVVRMPRKCBHPRD
S840SAFTTsTVVRMPRKCAHPRD
S654IGIGLsPAMSY7tm_3; TMPhosphoSitePlus
S256NAGEQsFDKLLANF_receptorPhosphoSitePlus
T282FCEGMtVRGLLANF_receptorPhosphoSitePlus
S1020RPRSPsPISTLPhosphoSitePlus
S840SAFTTsTVVRMPRKCQHPRD
S840SAFTTsTVVRMPRKCEHPRD
S266LKKLTsHLPKAANF_receptorPhosphoSitePlus
S250SYKIYsNAGEQANF_receptorPhosphoSitePlus
Y619SRELCyIILAG7tm_3; TMPhosphoSitePlus

Dephosphorylation site
GRM5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305905R574*COSMICBreast Cancer20668451
ENSP00000306138W354GBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905A855TCOSMICOvarian Cancer21720365
ENSP00000402912R435WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000305905W354GBIOMARTBreast Cancer21930507, 21930502
ENSP00000306138R435WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000305905P536LCOSMICSkin Cancer21984974
ENSP00000306138E527KBIOMARTBreast Cancer21930507, 21930502
ENSP00000402912W354GBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905G92RCOSMICOvarian Cancer21720365
ENSP00000305905P32LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000305905R78KCOSMICSkin Cancer21984974
ENSP00000405690E527KBIOMARTBreast Cancer21930507, 21930502
ENSP00000402912E527KBIOMARTBreast Cancer21930507, 21930502
ENSP00000402912D545HBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905R128HCOSMICLung Cancer20668451
ENSP00000405690D545HBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905R435WCOSMICHead and Neck Cancer21798893
ENSP00000305905F818LCOSMICHead and Neck Cancer21798893
ENSP00000305905D545HBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905K51ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000405690W354GBIOMARTBreast Cancer21930507, 21930502
ENSP00000405690R435WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000305905E527KBIOMARTBreast Cancer21930507, 21930502
ENSP00000305905N769ICOSMICLung Cancer20668451
ENSP00000306138D545HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
GRM5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRM5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCT_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCB_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCA_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCZ_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCG_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCE_HUMANGRM5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa05016Huntington's disease
hsa04730Long-term depression
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007626locomotory behaviorIEAbiological_process
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0040013negative regulation of locomotionIEAbiological_process
GO:0002029desensitization of G-protein coupled receptor protIEAbiological_process
GO:0007206phospholipase C-activating G-protein coupled glutaTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0008066glutamate receptor activityTASmolecular_function
GO:0007268synaptic transmissionIEAbiological_process
GO:0000185activation of MAPKKK activityIEAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0048170positive regulation of long-term neuronal synapticIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0007612learningIEAbiological_process
GO:0031687A2A adenosine receptor bindingIEAmolecular_function


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