| UniProt/SwissProt ID: | GRM4_HUMAN |
| Description: | glutamate receptor, metabotropic 4 [Source:HGNC Symbol;Acc:4596] |
| Location: | chr6 p21.31 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S138 | EVRCGsGGPPI | ANF_receptor | PhosphoSitePlus |
| Y555 | YQVDRyTCKTC | NCD3G | PhosphoSitePlus |
| T145 | GPPIItKPERV | ANF_receptor | PhosphoSitePlus |
| Y414 | VIDAVyAMGHA | ANF_receptor | PhosphoSitePlus |
| Y562 | CKTCPyDMRPT | NCD3G | PhosphoSitePlus |
| S138 | EVRCGsGGPPI | HPRD | |
| T145 | GPPIItKPERV | HPRD | |
| Dephosphorylation site |
| GRM4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363296 | V824F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363296 | M761I | COSMIC | Lung Cancer | 20668451 | ENSP00000363296 | C109Y | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000363296 | Q207K | COSMIC | Lung Cancer | 20668451 | ENSP00000363296 | R44C | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000363296 | G457S | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000363296 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.27 | 15169874 |
| Hyperphosphorylation site |
| GRM4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DCE1_HUMAN | GRM4_HUMAN | ligand -> receptor | HPMR |
| GRM4_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| GRM4_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GRM4_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GRM4_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04742 | Taste transduction |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04724 | Glutamatergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | IDA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0043195 | terminal button | IEA | cellular_component |
| GO:0007269 | neurotransmitter secretion | TAS | biological_process |
| GO:0007612 | learning | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0043410 | positive regulation of MAPK cascade | IEP | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0008066 | glutamate receptor activity | TAS | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0043523 | regulation of neuron apoptotic process | TAS | biological_process |
| GO:0031410 | cytoplasmic vesicle | IDA | cellular_component |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0000187 | activation of MAPK activity | IDA | biological_process |
| GO:0048787 | presynaptic active zone membrane | IEA | cellular_component |
| GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glu | IMP | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0043198 | dendritic shaft | IEA | cellular_component |