Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRM4_HUMAN
Description:glutamate receptor, metabotropic 4 [Source:HGNC Symbol;Acc:4596]
Location:chr6 p21.31
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S138EVRCGsGGPPIANF_receptorPhosphoSitePlus
Y555YQVDRyTCKTCNCD3GPhosphoSitePlus
T145GPPIItKPERVANF_receptorPhosphoSitePlus
Y414VIDAVyAMGHAANF_receptorPhosphoSitePlus
Y562CKTCPyDMRPTNCD3GPhosphoSitePlus
S138EVRCGsGGPPIHPRD
T145GPPIItKPERVHPRD

Dephosphorylation site
GRM4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363296V824FCOSMICOvarian Cancer21720365
ENSP00000363296M761ICOSMICLung Cancer20668451
ENSP00000363296C109YCOSMICHepatocellular Carcinoma21822264
ENSP00000363296Q207KCOSMICLung Cancer20668451
ENSP00000363296R44CCOSMICHead and Neck Cancer21798897
ENSP00000363296G457SCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363296Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.2715169874

Hyperphosphorylation site
GRM4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DCE1_HUMANGRM4_HUMANligand -> receptorHPMR
GRM4_HUMANGNAI2_HUMANGPCR -> GproteingpDB
GRM4_HUMANGNAI3_HUMANGPCR -> GproteingpDB
GRM4_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM4_HUMANGNAI1_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04742Taste transduction
hsa04080Neuroactive ligand-receptor interaction
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007268synaptic transmissionIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0007269neurotransmitter secretionTASbiological_process
GO:0007612learningIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0043410positive regulation of MAPK cascadeIEPbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0008066glutamate receptor activityTASmolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0043523regulation of neuron apoptotic processTASbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0005622intracellularIDAcellular_component
GO:0000187activation of MAPK activityIDAbiological_process
GO:0048787presynaptic active zone membraneIEAcellular_component
GO:0007196adenylate cyclase-inhibiting G-protein coupled gluIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0043198dendritic shaftIEAcellular_component


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