| UniProt/SwissProt ID: | GRM3_HUMAN |
| Description: | glutamate receptor, metabotropic 3 [Source:HGNC Symbol;Acc:4595] |
| Location: | chr7 q21.11 |
| Node attribute: | GPCR; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y743 | LISLTyDVILV | 7tm_3; TM | PhosphoSitePlus |
| S255 | SNIRKsYDSVI | ANF_receptor | PhosphoSitePlus |
| T758 | VYAFKtRKCPE | 7tm_3 | PhosphoSitePlus |
| Y478 | NVGGKySYLKV | PhosphoSitePlus | |
| Y480 | GGKYSyLKVGH | PhosphoSitePlus | |
| Y466 | DGMGRyNVFNF | ANF_receptor | PhosphoSitePlus |
| Y754 | ILCTVyAFKTR | 7tm_3; TM | PhosphoSitePlus |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S845 | RLHLNRFsVSGTGTT | PPM1A | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355316 | C751* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355316 | S496T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355316 | I696T | COSMIC | Lung Cancer | 20668451 | ENSP00000355316 | G88E | COSMIC | Melanoma | 21946352 | ENSP00000355316 | C534R | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000355316 | E517K | COSMIC | Melanoma | 21946352 | ENSP00000355316 | E870K | COSMIC | Melanoma | 21946352 | ENSP00000355316 | V468L | COSMIC | Melanoma | 21946352 | ENSP00000355316 | T758M | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000355316 | D77Y | COSMIC | Lung Cancer | 20668451 | ENSP00000355316 | R352W | COSMIC | Melanoma | 21946352 | ENSP00000355316 | F682L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355316 | D511N | COSMIC | Melanoma | 21946352 | ENSP00000355316 | Y336H | COSMIC | Lung Cancer | 20668451 | ENSP00000355316 | G58R | COSMIC | Prostate Cancer | 20668451 | ENSP00000355316 | D280N | COSMIC | Melanoma | 21946352 | ENSP00000355316 | S610L | COSMIC | Melanoma | 21946352 | ENSP00000355316 | L20F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355316 | R723W | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000355316 | E573K | COSMIC | Melanoma | 21946352 | ENSP00000355316 | S496T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000355316 | G18E | COSMIC | Melanoma | 21946352 | ENSP00000355316 | A305V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355316 | R183C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000355316 | S154F | COSMIC | Melanoma | 21946352 | ENSP00000355316 | G92S | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000355316 | E767K | COSMIC | Melanoma | 21946352 | ENSP00000355316 | D548N | COSMIC | Melanoma | 21946352 | ENSP00000355316 | R59Q | COSMIC | Melanoma | 21946352 | ENSP00000355316 | G848E | COSMIC | Melanoma | 21946352 | ENSP00000355316 | G561E | COSMIC | Melanoma | 21946352 | ENSP00000355316 | P192L | COSMIC | Melanoma | 21946352 | ENSP00000355316 | V271I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000355316 | N251Y | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GRM3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRM3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRM3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GRM3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GRM3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GRM3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| PPM1A_HUMAN | GRM3_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa05030 | Cocaine addiction |
| hsa04724 | Glutamatergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005246 | calcium channel regulator activity | IEA | molecular_function |
| GO:0001641 | group II metabotropic glutamate receptor activity | IEA | molecular_function |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0050804 | regulation of synaptic transmission | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0043197 | dendritic spine | IEA | cellular_component |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0008066 | glutamate receptor activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0042734 | presynaptic membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |