| UniProt/SwissProt ID: | GRM2_HUMAN |
| Description: | glutamate receptor, metabotropic 2 [Source:HGNC Symbol;Acc:4594] |
| Location: | chr3 p21.2 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S246 | VGRAMsRAAFE | ANF_receptor | PhosphoSitePlus |
| S501 | PASRCsEPCLQ | NCD3G | PhosphoSitePlus |
| S111 | VRASLsRGADG | ANF_receptor | PhosphoSitePlus |
| S109 | DFVRAsLSRGA | ANF_receptor | PhosphoSitePlus |
| T457 | RYNIFtYLRAG | ANF_receptor | PhosphoSitePlus |
| Dephosphorylation site |
| GRM2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378492 | T868K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| GRM2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRM2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRM2_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| GRM2_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GRM2_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GRM2_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04724 | Glutamatergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa05030 | Cocaine addiction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042734 | presynaptic membrane | IEA | cellular_component |
| GO:0001641 | group II metabotropic glutamate receptor activity | IEA | molecular_function |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005246 | calcium channel regulator activity | IEA | molecular_function |
| GO:0008066 | glutamate receptor activity | TAS | molecular_function |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0014047 | glutamate secretion | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |