| UniProt/SwissProt ID: | GNAZ_HUMAN |
| Description: | guanine nucleotide binding protein (G protein), alpha z polypeptide [Source:HGNC Symbol;Acc:4395] |
| Location: | chr22 q11.22 |
| Node attribute: | Gprotein; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S16 | EAARRsRRIDR | G-alpha; DUF2951 | PhosphoSitePlus |
| S16 | EAARRsRRIDR | PRKCD | HPRD |
| S27 | HLRSEsQRQRR | PKC_group | phosphoELM |
| S16 | EAARRsRRIDR | PKC_alpha | phosphoELM |
| S142 | AQACFsRSSEY | G-alpha | PhosphoSitePlus |
| S229 | FCVELsGYDLK | G-alpha | PhosphoSitePlus |
| S27 | HLRSEsQRQRR | PKC_alpha | phosphoELM |
| T341 | VFDAVtDVIIQ | G-alpha | PhosphoSitePlus |
| T263 | NWFINtSLILF | G-alpha | PhosphoSitePlus |
| S264 | WFINTsLILFL | G-alpha | PhosphoSitePlus |
| S16 | EAARRsRRIDR | PKC_group | phosphoELM |
| S27 | HLRSEsQRQRR | G-alpha; DUF2951 | PhosphoSitePlus |
| Y231 | VELSGyDLKLY | G-alpha | PhosphoSitePlus |
| S27 | HLRSEsQRQRR | PRKCD | HPRD |
| S16 | EAARRsRRIDR | PAK1 | phosphoELM |
| Dephosphorylation site |
| GNAZ_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000248996 | D151N | COSMIC | Melanoma | 21499247 | ENSP00000248996 | N43S | COSMIC | Melanoma | 20424519 | ENSP00000248996 | S80L | COSMIC | Melanoma | 20424519 | ENSP00000248996 | P98S | COSMIC | Melanoma | 20424519 |
| Differential expressed protein |
| GNAZ_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GNAZ_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| C3AR_HUMAN | GNAZ_HUMAN | GPCR -> Gprotein | gpDB |
| FPR1_HUMAN | GNAZ_HUMAN | GPCR -> Gprotein | gpDB |
| PKN1_HUMAN | GNAZ_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| KPCD_HUMAN | GNAZ_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | GNAZ_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04730 | Long-term depression |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | IBA | cellular_component |
| GO:0005783 | endoplasmic reticulum | TAS | cellular_component |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | IEA | biological_process |
| GO:0031821 | G-protein coupled serotonin receptor binding | IBA | molecular_function |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA | molecular_function |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IBA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005057 | receptor signaling protein activity | TAS | molecular_function |
| GO:0031234 | extrinsic to internal side of plasma membrane | IBA | cellular_component |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | IBA | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0003924 | GTPase activity | IBA | molecular_function |
| GO:0019001 | guanyl nucleotide binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005635 | nuclear envelope | TAS | cellular_component |
| GO:0031821 | G-protein coupled serotonin receptor binding | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IBA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |