| UniProt/SwissProt ID: | ERCC8_HUMAN |
| Description: | excision repair cross-complementing rodent repair deficiency, complementation group 8 [Source:HGNC Symbol;Acc:3439] |
| Location: | chr5 q12.1 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y71 | GVIVLyDLENS | WD40 | PhosphoSitePlus |
| S392 | DAWSSsDE | HPRD | |
| S390 | FEDAWsSSDEE | PhosphoSitePlus | |
| S391 | EDAWSsSDEEG | PhosphoSitePlus | |
| S391 | EDAWSsSDE | HPRD | |
| T154 | MSPVStKHCLV | PhosphoSitePlus | |
| S392 | DAWSSsDEEG_ | PhosphoSitePlus | |
| S390 | FEDAWsSSDE | HPRD | |
| Dephosphorylation site |
| ERCC8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265038 | W127C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265038 | D371H | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ERCC8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ERCC8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ERCC8_HUMAN | THA_HUMAN | other | KEGG |
| ERCC8_HUMAN | GHR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa03420 | Nucleotide excision repair |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0000109 | nucleotide-excision repair complex | IDA | cellular_component |
| GO:0006289 | nucleotide-excision repair | IMP | biological_process |
| GO:0006283 | transcription-coupled nucleotide-excision repair | IDA | biological_process |
| GO:0043234 | protein complex | IDA | cellular_component |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0009411 | response to UV | IEA | biological_process |
| GO:0000209 | protein polyubiquitination | IDA | biological_process |
| GO:0032403 | protein complex binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0010165 | response to X-ray | IEA | biological_process |
| GO:0006979 | response to oxidative stress | IDA | biological_process |
| GO:0045739 | positive regulation of DNA repair | IMP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0051865 | protein autoubiquitination | IDA | biological_process |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IDA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |