Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERCC8_HUMAN
Description:excision repair cross-complementing rodent repair deficiency, complementation group 8 [Source:HGNC Symbol;Acc:3439]
Location:chr5 q12.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y71GVIVLyDLENSWD40PhosphoSitePlus
S392DAWSSsDEHPRD
S390FEDAWsSSDEEPhosphoSitePlus
S391EDAWSsSDEEGPhosphoSitePlus
S391EDAWSsSDEHPRD
T154MSPVStKHCLVPhosphoSitePlus
S392DAWSSsDEEG_PhosphoSitePlus
S390FEDAWsSSDEHPRD

Dephosphorylation site
ERCC8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265038W127CBIOMARTBreast Cancer21930507, 21930502
ENSP00000265038D371HCOSMICHead and Neck Cancer21798893

Differential expressed protein
ERCC8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ERCC8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ERCC8_HUMANTHA_HUMANotherKEGG
ERCC8_HUMANGHR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa03420Nucleotide excision repair

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016363nuclear matrixIDAcellular_component
GO:0000109nucleotide-excision repair complexIDAcellular_component
GO:0006289nucleotide-excision repairIMPbiological_process
GO:0006283transcription-coupled nucleotide-excision repairIDAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0031464Cul4A-RING ubiquitin ligase complexIDAcellular_component
GO:0009411response to UVIEAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0032403protein complex bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0010165response to X-rayIEAbiological_process
GO:0006979response to oxidative stressIDAbiological_process
GO:0045739positive regulation of DNA repairIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic IDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0006281DNA repairTASbiological_process


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