Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BCL6_HUMAN
Description:B-cell CLL/lymphoma 6 [Source:HGNC Symbol;Acc:1001]
Location:chr3 q27.3
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S308EERPSsEDEIAHPRD
S337QSPQKsDCQPNPhosphoSitePlus
S333LVSPQsPQKSDPhosphoSitePlus
T653HLRIHtGEKPYzf-H2C2_2PhosphoSitePlus
T569HKTVHtGEKPYzf-H2C2_2PhosphoSitePlus
S330RKGLVsPQSPQPhosphoSitePlus
T625HVLIHtGEKPYzf-H2C2_2PhosphoSitePlus
S343DCQPNsPTESCPhosphoSitePlus
Y574TGEKPyRCNICzf-H2C2_2PhosphoSitePlus
Y157QDIMAyRGREVPhosphoSitePlus

Dephosphorylation site
BCL6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384371G159SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000232014D437YCOSMICOvarian Cancer20668451
ENSP00000232014G159SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000232014S359FDing2008, COSMICLung Cancer18948947
ENSP00000384371S359FDing2008, COSMICLung Cancer18948947
ENSP00000384371D437YCOSMICOvarian Cancer20668451
ENSP00000384371R289*COSMICHead and Neck Cancer21798893
ENSP00000232014R289*COSMICHead and Neck Cancer21798893
ENSP00000384371Y293FCOSMICOvarian Cancer21720365
ENSP00000232014Y293FCOSMICOvarian Cancer21720365
ENSP00000232014E514*Ding2008, COSMICLung Cancer18948947
ENSP00000384371E514*Ding2008, COSMICLung Cancer18948947

Differential expressed protein
BCL6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BCL6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANBCL6_HUMANkinase -> substrateNetPath
FOXO4_HUMANBCL6_HUMANTF -> target geneTRANSFAC
BCL6_HUMANP53_HUMANTF -> target geneTRANSFAC
BCL6_HUMANB2CL1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032764negative regulation of mast cell cytokine productiIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0045629negative regulation of T-helper 2 cell differentiaIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0051272positive regulation of cellular component movementIEAbiological_process
GO:0001953negative regulation of cell-matrix adhesionIEAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0002829negative regulation of type 2 immune responseIEAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIMPmolecular_function
GO:0048294negative regulation of isotype switching to IgE isIEAbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0042092type 2 immune responseIEAbiological_process
GO:0032319regulation of Rho GTPase activityIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0043380regulation of memory T cell differentiationIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0000060protein import into nucleus, translocationIGIbiological_process
GO:0005657replication forkIDAcellular_component
GO:0045749negative regulation of S phase of mitotic cell cycNASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0050776regulation of immune responseNASbiological_process
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0035024negative regulation of Rho protein signal transducIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0002634regulation of germinal center formationNASbiological_process
GO:0002903negative regulation of B cell apoptotic processNASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008104protein localizationIEAbiological_process
GO:0002467germinal center formationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0048821erythrocyte developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function