Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EZRI_HUMAN
Description:ezrin [Source:HGNC Symbol;Acc:12691]
Location:chr6 q25.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y478PPPPVyEPVSYSrcRegPhos
T468LHLVMtAPPPPERMPhosphoSitePlus
Y483YEPVSyHVQESERMPhosphoSitePlus
T567RDKYKtLRQIRERMPhosphoSitePlus
Y478PPPPVyEPVSYERMPhosphoSitePlus
Y424AELAEyTAKIAERMPhosphoSitePlus
Y354LRLQDyEEKTKEGFRHPRD; phosphoELM; RegPhos
Y146VHKSGyLSSERPDGFR_groupRegPhos
S488YHVQEsLQDEGERMPhosphoSitePlus
T567RDKYKtLRQIRROCK1HPRD; phosphoELM; RegPhos
S112KEGILsDEIYCFERM_MPhosphoSitePlus
T576IRQGNtKQRIDERMPhosphoSitePlus
S539LSSELsQARDEERMPhosphoSitePlus
Y146VHKSGyLSSERLckphosphoELM; RegPhos
T567RDKYKtLRQIRphosphoELM
Y201QDLEMyGINYFFERM_MPhosphoSitePlus
Y146VHKSGyLSSERLCKHPRD; RegPhos
Y499AEPTGySAELSERMPhosphoSitePlus
T235KDDKLtPKIGFCDK5HPRD; RegPhos
Y146VHKSGyLSSEREGFRHPRD; phosphoELM; RegPhos
T567RDKYKtLRQIRAkt2(PKB betaRegPhos
Y116LSDEIyCPPETFERM_MPhosphoSitePlus
T567RDKYKtLRQIRPRKCAHPRD
S482VYEPVsYHVQEERMPhosphoSitePlus
Y291GNHELyMRRRKFERM_CPhosphoSitePlus
Y137AKFGDyNKEVHFERM_MPhosphoSitePlus
T497EGAEPtGYSAEERMPhosphoSitePlus
T332KKRREtVEREKPhosphoSitePlus
S535QLLTLsSELSQERMPhosphoSitePlus
Y146VHKSGyLSSERFERM_MPhosphoSitePlus
T567RDKYKtLRQIRBARK1(GRK2RegPhos
Y565QGRDKyKTLRQERMPhosphoSitePlus
T567RDKYKtLRQIRPKCaRegPhos
T567RDKYKtLRQIRPKB_betaphosphoELM
T567RDKYKtLRQIRGRK-2phosphoELM
Y191NAMLEyLKIAQFERM_MPhosphoSitePlus
T548DENKRtHNDIIERMPhosphoSitePlus
Y354LRLQDyEEKTKPDGFR_groupRegPhos
S149SGYLSsERLIPFERM_MPhosphoSitePlus
S539LSSELsQARDEHPRD
Y270PDFVFyAPRLRFERM_CPhosphoSitePlus
T425ELAEYtAKIALERMPhosphoSitePlus
Y354LRLQDyEEKTKERMPhosphoSitePlus
S536LLTLSsELSQAHPRD
S66LDKKVsAQEVRFERM_NPhosphoSitePlus
Y205MYGINyFEIKNFERM_MPhosphoSitePlus
Y478PPPPVyEPVSYSRCphosphoELM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y146KEVHKSGyLSSERLIPTPRCHPRD

Mutation site
EZRI_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356042Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000356042Prostate CancerMetastasistissueUp2.318553995
ENSP00000356042Esophageal CancerNormal vs. CancertissueDown0.4819142970
ENSP00000356042Breast CancerNormal vs. Cancercell lineDown0.2916596714
ENSP00000356042Breast CancerNormal vs. Cancercell lineDown0.2316596714
ENSP00000356042Breast CancerNormal vs. Cancercell lineDown0.316596714
ENSP00000356042Breast CancerNormal vs. Cancercell lineDown0.1616596714
ENSP00000356042Breast CancerMetastasistissueUp18257521
ENSP00000356042Hepatocellular CarcinomaNormal vs. Cancercell lineUp5.419120023
ENSP00000356042Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000356042Lung CancerCancer vs. Cancercell lineDown17284061
ENSP00000356042Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217
ENSP00000356042Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1820858016
ENSP00000356042Biliary Tract CancerMetastasiscell lineUp3.719299076

Hyperphosphorylation site
EZRI_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PGFRB_HUMANEZRI_HUMANkinase -> substrateRegPhos
FAK2_HUMANEZRI_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANEZRI_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANEZRI_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
EGFR_HUMANEZRI_HUMANkinase -> substrateRegPhos
ROCK1_HUMANEZRI_HUMANkinase -> substrateHPRD; RegPhos
ARBK1_HUMANEZRI_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANEZRI_HUMANkinase -> substrateHPRD
PTPRC_HUMANEZRI_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04971Gastric acid secretion
hsa05130Pathogenic Escherichia coli infection
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0045177apical part of cellIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032587ruffle membraneIEAcellular_component
GO:0035088establishment or maintenance of apical/basal cell IEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0031528microvillus membraneIEAcellular_component
GO:0019898extrinsic to membraneIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0022614membrane to membrane dockingIEPbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0016323basolateral plasma membraneISScellular_component
GO:0007016cytoskeletal anchoring at plasma membraneNASbiological_process
GO:0030863cortical cytoskeletonTAScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0005902microvillusIEAcellular_component
GO:0050839cell adhesion molecule bindingIPImolecular_function
GO:0001726ruffleIDAcellular_component
GO:0030175filopodiumIDAcellular_component
GO:0005902microvillusIDAcellular_component
GO:0005884actin filamentIDAcellular_component
GO:0005925focal adhesionIDAcellular_component
GO:0051015actin filament bindingIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0051017actin filament bundle assemblyIDAbiological_process
GO:0007159leukocyte cell-cell adhesionIEPbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005932microtubule basal bodyIEAcellular_component
GO:0001931uropodIEAcellular_component
GO:0005730nucleolusIDAcellular_component


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