Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERF_HUMAN
Description:Ets2 repressor factor [Source:HGNC Symbol;Acc:3444]
Location:chr19 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T526AGGPLtPRRVSMAPK1HPRD; phosphoELM; SysPTM
S251SPFPVsPLAGPErk2RegPhos
S444EVTDIsDEDEEPhosphoSitePlus; HPRD; phosphoELM
S435ISEGEsEEVEVPhosphoSitePlus; HPRD; phosphoELM
S327YNYHLsPRAFLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S251SPFPVsPLAGPPhosphoSitePlus; phosphoELM
S190SVSDCsDGTSEHPRD; phosphoELM; RegPhos
T526AGGPLtPRRVSErk2RegPhos; SysPTM
T526AGGPLtPRRVSErk2(MAPK1RegPhos; SysPTM
T156EVLSPtEDPRSPhosphoSitePlus; HPRD; phosphoELM
S532PRRVSsDLQHAPhosphoSitePlus
S548LEHRHPRD; phosphoELM
S161TEDPRsPPACSErk2RegPhos
S370SSSSSsSSSPFPhosphoSitePlus
S548LEHRDs_____PhosphoSitePlus
S531TPRRVsSDLQHPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S368SASSSsSSSSSPhosphoSitePlus
T3ADTGHPRD; phosphoELM
S21YKPESsPGSRQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T357PMAPEtPPVPSPhosphoSitePlus
S20AYKPEsSPGSRPhosphoSitePlus; HPRD; phosphoELM
S431KVEPIsEGESEPhosphoSitePlus; HPRD; phosphoELM
T526AGGPLtPRRVSPhosphoSitePlus; phosphoELM; SysPTM
S246GPEPLsPFPVSMAPK1HPRD
T7FAFPHPRD; phosphoELM
S154PSEVLsPTEDPPhosphoSitePlus; HPRD; phosphoELM
S246GPEPLsPFPVSPhosphoSitePlus; phosphoELM
S542ATAQLsLEHRDPhosphoSitePlus
S150PPSTPsEVLSPHPRD; phosphoELM
T7KTPADtGFAFPPhosphoSitePlus
S246GPEPLsPFPVSErk2(MAPK1RegPhos
S161TEDPRsPPACSErk2(MAPK1RegPhos
S369ASSSSsSSSSPPhosphoSitePlus
S246GPEPLsPFPVSErk2RegPhos
T456GEVFKtPRAPPPhosphoSitePlus
S251SPFPVsPLAGPErk2(MAPK1RegPhos
T3___MKtPADTGPhosphoSitePlus
S251SPFPVsPLAGPMAPK1HPRD
S367SSASSsSSSSSPhosphoSitePlus
S161TEDPRsPPACSPhosphoSitePlus; phosphoELM
S24ESSPGsRQIQLPhosphoSitePlus
S171SSSSSsLFSAVPhosphoSitePlus; HPRD; phosphoELM
S187GRGSVsDCSDGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T148RFPPStPSEVLHPRD; phosphoELM
S185RLGRGsVSDCSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T441EEVEVtDISDEPhosphoSitePlus; HPRD; phosphoELM
S147FRFPPsTPSEVPhosphoSitePlus; HPRD; phosphoELM
S489FKRRWsEDCRLHPRD; SysPTM
S161TEDPRsPPACSMAPK1HPRD; phosphoELM
Y16FPDWAyKPESSPhosphoSitePlus; HPRD; phosphoELM
Y324R.YLQAHTQSVYNYHLSPR.ASysPTM 2.0

Dephosphorylation site
ERF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222329G522VCOSMICLung Cancer20668451
ENSP00000222329P155TCOSMICRenal Cancer20054297
ENSP00000222329G497DCOSMICCentral Nervous System Neoplasms18772396
ENSP00000222329H325NCOSMICMelanoma

Differential expressed protein
ERF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ERF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANERF_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
DYR1B_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANERF_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
ERF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0007049cell cycleNASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0010668ectodermal cell differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0060710chorio-allantoic fusionIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0060707trophoblast giant cell differentiationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process